ArticleEuropean journal of histochemistry : EJH2011
Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer.
Article in European journal of histochemistry : EJH, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
- Non-coding RNAs, a double-edged sword in breast cancer prognosis.Cancer cell international · 2025Review
- Article
- Nestin Expression as a Diagnostic and Prognostic Marker in Colorectal Cancer and Other Tumors.Clinical Medicine Insights. Oncology · 2021Review
- Clinicopathological and prognostic significance of nestin expression in patients with breast cancer: a systematic review and meta-analysis.Cancer cell international · 2020Article
- Article
- The Structural Function of Nestin in Cell Body Softening is Correlated with Cancer Cell Metastasis.International journal of biological sciences · 2019Article
- Nestin expression in breast cancer: association with prognosis and subtype on 3641 cases with long-term follow-up.Breast cancer research and treatment · 2018Article
- Immunophenotypic characterization of telocyte-like cells in pterygium.Molecular vision · 2018Article
- RNAi-mediated human Nestin silence inhibits proliferation and migration of malignant melanoma cells by GJournal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- A target of potential RELAvance in inflammatory breast cancer.Oncotarget · 2017Article
- Nestin suppression attenuates invasive potential of endometrial cancer cells by downregulating TGF-β signaling pathway.Oncotarget · 2016Article
- Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer.Oncology letters · 2015Article
- Prognostic significance of neural stem cell markers, Nestin and Musashi-1, in oral squamous cell carcinoma: expression pattern of Nestin in the precancerous stages of oral squamous epithelium.Clinical oral investigations · 2015Article
- Nestin depletion induces melanoma matrix metalloproteinases and invasion.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells.Breast cancer research : BCR · 2014Article
- Nestin: predicting specific survival factors for breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Histochemistry as an irreplaceable approach for investigating functional cytology and histology.European journal of histochemistry : EJH · 2013Article
- Nestin and its emerging role in tumor progression and carcinogenesis in systemic tumors besides pancreatic carcinomas.Medical molecular morphology · 2013Article
- On the future contents of a small journal of histochemistry.European journal of histochemistry : EJH · 2012Article
- Identifying pathological biomarkers: histochemistry still ranks high in the omics era.European journal of histochemistry : EJH · 2011Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients' outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers.
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