ArticleBiological psychiatry2012
Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Unraveling the genes implicated in Alzheimer's disease.Biomedical reports · 2017Article
- Genome-wide association study of antisocial personality disorder.Translational psychiatry · 2016Article
- A Rare Recurrent 4q25 Proximal Deletion Not Involving the PITX2 Gene: A Genomic Disorder Distinct from Axenfeld-Rieger Syndrome.Molecular syndromology · 2016Article
- Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.Scientific reports · 2016Article
- Genome-wide association study of copy number variations (CNVs) with opioid dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders.Brain imaging and behavior · 2014Review
- Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes.PLoS genetics · 2013Article
- Genomic variants and inferred biological processes in multiplex families with Tourette syndrome.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundAntisocial personality disorder (ASPD) is a psychiatric disorder characterized by a long-term pattern of manipulating, exploiting, or violating the rights of others.
methodsSubjects ascertained for genetic studies of substance dependence (SD) and diagnosed with ASPD and comorbid SD were included in a two-stage genetic association study. In the discovery stage, 627 single nucleotide polymorphisms (SNPs) located in 179 candidate genes for addiction were analyzed in a case-control cohort and family-based cohort. The significant findings were replicated in an independent case-control cohort.
resultsOne SNP, rs13134663, in the collagen XXV alpha 1 gene (COL25A1) was significantly associated with ASPD in both African Americans and European Americans (smallest p values were .0002 and .0004, respectively). There was also evidence of association with the same SNP in independent samples of African American and European American cases and control subjects (p = .035 and .033, respectively). Analysis of the combined set of case-control subjects yielded an allelic p value of 9 × 10(-6) with odds ratio (95% confidence interval) of 1.3 (1.16, 1.47) (smallest p = 1 × 10(-7); Bonferroni threshold p = .00012).
conclusionsThe COL25A1 gene, located at chromosome 4q25, encodes the collagen-like Alzheimer amyloid plaque component precursor, a type II transmembrane protein specifically expressed in neurons; it co-localizes with amyloid β in senile plaques in Alzheimer disease brains. This SNP maps to the transcription factor binding site and is conserved in 17 vertebrates, including mice and rats. Our findings suggest that COL25A1 may be associated with ASPD, especially in the context of SD.
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