SynthesisJournal of psychiatry & neuroscience : JPN2012
Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies.
Synthesis in Journal of psychiatry & neuroscience : JPN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Structural brain correlates of interpersonal violence: Systematic review and voxel-based meta-analysis of neuroimaging studies.Psychiatry research. Neuroimaging · 2017Pooled it
- Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents.European child & adolescent psychiatry · 2014Pooled it
- Catching the Storm Before It Breaks: Advancing Early Diagnosis and Intervention in Bipolar Disorder.Life (Basel, Switzerland) · 2025Review
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- A Plea for Nuance: Should People with a Family History of Bipolar Disorder Be Excluded from Clinical Trials of Psilocybin Therapy?Psychedelic medicine (New Rochelle, N.Y.) · 2024Review
- Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder: A Danish Register-based Study.Schizophrenia bulletin · 2024Article
- The Risk for Schizophrenia-Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review.International journal of environmental research and public health · 2023Review
- Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.Molecular psychiatry · 2023Review
- Gray Matter Abnormalities in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Brain sciences · 2022Review
- Associations Between Parental Mood and Anxiety Psychopathology and Offspring Brain Structure: A Scoping Review.Clinical child and family psychology review · 2022Article
- Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.Translational psychiatry · 2021Article
- Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Three-Dimensional Convolutional Autoencoder Extracts Features of Structural Brain Images With a "Diagnostic Label-Free" Approach: Application to Schizophrenia Datasets.Frontiers in neuroscience · 2021Article
- Aberrant structural covariance networks in youth at high familial risk for mood disorder.Bipolar disorders · 2020Article
- Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks.Molecular psychiatry · 2019Review
- Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar Disorder.Current psychiatry reports · 2019Review
- Brain Age in Early Stages of Bipolar Disorders or Schizophrenia.Schizophrenia bulletin · 2019Article
- Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAlthough early interventions in individuals with bipolar disorder may reduce the associated personal and economic burden, the neurobiologic markers of enhanced risk are unknown.
methodsNeuroimaging studies involving individuals at enhanced genetic risk for bipolar disorder (HR) were included in a systematic review. We then performed a region of interest (ROI) analysis and a whole-brain meta-analysis combined with a formal effect-sizes meta-analysis in a subset of studies.
resultsThere were 37 studies included in our systematic review. The overall sample for the systematic review included 1258 controls and 996 HR individuals. No significant differences were detected between HR individuals and controls in the selected ROIs: striatum, amygdala, hippocampus, pituitary and frontal lobe. The HR group showed increased grey matter volume compared with patients with established bipolar disorder. The HR individuals showed increased neural response in the left superior frontal gyrus, medial frontal gyrus and left insula compared with controls, independent from the functional magnetic resonance imaging task used. There were no publication biases. Sensitivity analysis confirmed the robustness of these results. LIMITATIONS: As the included studies were cross-sectional, it remains to be determined whether the observed neurofunctional and structural alterations represent risk factors that can be clinically used in preventive interventions for prodromal bipolar disorder.
conclusionAccumulating structural and functional imaging evidence supports the existence of neurobiologic trait abnormalities in individuals at genetic risk for bipolar disorder at various scales of investigation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.