SynthesisJournal of psychiatry & neuroscience : JPN2012
Systematic review of the neural basis of social cognition in patients with mood disorders.
Synthesis in Journal of psychiatry & neuroscience : JPN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Systematic Review and Meta-Analysis of the Association Between Subjective and Objective Cognitive Function in Mood Disorders.Bipolar disorders · 2026Pooled it
- Theory of mind performance in depression: A meta-analysis.Journal of affective disorders · 2022Pooled it
- Altered Brain Activity in Unipolar Depression Revisited: Meta-analyses of Neuroimaging Studies.JAMA psychiatry · 2017Pooled it
- Pooled it
- Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Moral emotion processing in euthymic bipolar disorder: insights from network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Exploring the Associations Between Affective and Non-Affective Cognitive Domains in Mood Disorders and Healthy Controls Using Network Analysis.Acta psychiatrica Scandinavica · 2026Article
- Association of retinal layer thickness with brain volume and cortical thickness in older adults.Scientific reports · 2025Article
- Discrepancy of social cognition between bipolar disorders and major depressive disorders.Brain and behavior · 2024Article
- Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale.World journal of clinical cases · 2023Article
- Visual Event-Related Potentials under External Emotional Stimuli in Bipolar I Disorder with and without Hypersexuality.Brain sciences · 2022Article
- Semantics-Prosody Stroop Effect on English Emotion Word Processing in Chinese College Students With Trait Depression.Frontiers in psychiatry · 2022Article
- Organization of the social cognition network predicts future depression and interpersonal impairment: a prospective family-based study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Family history of depression is associated with alterations in task-dependent connectivity between the cerebellum and ventromedial prefrontal cortex.Depression and anxiety · 2021Article
- Piecing together the orbitofrontal puzzle.Behavioral neuroscience · 2021Article
- Self-other referential neural processing in social anxiety disorder and major depressive disorder.NeuroImage. Clinical · 2021Article
- Brain structural correlates of alexithymia in patients with major depressive disorderJournal of psychiatry & neuroscience : JPN · 2020Article
- Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder.CNS neuroscience & therapeutics · 2018Article
- Destination memory: the relationship between memory and social cognition.Psychological research · 2018Review
- A shared effect of paroxetine treatment on gray matter volume in depressive patients with and without childhood maltreatment: A voxel-based morphometry study.CNS neuroscience & therapeutics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis review integrates neuroimaging studies of 2 domains of social cognition--emotion comprehension and theory of mind (ToM)--in patients with major depressive disorder and bipolar disorder. The influence of key clinical and method variables on patterns of neural activation during social cognitive processing is also examined.
methodsStudies were identified using PsycINFO and PubMed (January 1967 to May 2011). The search terms were "fMRI," "emotion comprehension," "emotion perception," "affect comprehension," "affect perception," "facial expression," "prosody," "theory of mind," "mentalizing" and "empathy" in combination with "major depressive disorder," "bipolar disorder," "major depression," "unipolar depression," "clinical depression" and "mania."
resultsTaken together, neuroimaging studies of social cognition in patients with mood disorders reveal enhanced activation in limbic and emotion-related structures and attenuated activity within frontal regions associated with emotion regulation and higher cognitive functions. These results reveal an overall lack of inhibition by higher-order cognitive structures on limbic and emotion-related structures during social cognitive processing in patients with mood disorders. Critically, key variables, including illness burden, symptom severity, comorbidity, medication status and cognitive load may moderate this pattern of neural activation. LIMITATIONS: Studies that did not include control tasks or a comparator group were included in this review.
conclusionFurther work is needed to examine the contribution of key moderator variables and to further elucidate the neural networks underlying altered social cognition in patients with mood disorders. The neural networks under lying higher-order social cognitive processes, including empathy, remain unexplored in patients with mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.