SynthesisJournal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology2012
Changes in pain sensitivity following spinal manipulation: a systematic review and meta-analysis.
Synthesis in Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 84 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcutaneous Electrical Nerve Stimulation and Cervical Joint Manipulation on Pressure Pain Threshold
Hypoalgesic Effects of Specific vs Non-specific Cervical Manipulation in Healthy Subjects
Τhe Effect of Lumbar Spine Mobilization and Manipulation on Pressure Pain Threshold in Patients With Non-specific Chronic Low Back Pain: a Cross-over Randomised Controlled Trial
Who cites it
84 citing papers in PubMed, 12 syntheses or guidelines pooled it, 210 citations in OpenAlex.
- Research Waste in Randomised Control Trials of Spinal Manipulative Therapy for Chronic Low Back Pain: Evidence From Trial Sequential Analysis.European journal of pain (London, England) · 2026Pooled it
- The immediate effects of thoracic spine manipulation in patients with neck pain: a meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of spinal manipulative therapy in the management of acute neck pain: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation.Chiropractic & manual therapies · 2024Pooled it
- An overview of systematic reviews examining the quantitative sensory testing-derived hypoalgesic effects of manual therapy for musculoskeletal pain.The Journal of manual & manipulative therapy · 2024Pooled it
- Changes in biochemical markers following a spinal manipulation - a systematic review update.The Journal of manual & manipulative therapy · 2024Pooled it
- Does manual therapy meaningfully change quantitative sensory testing and patient reported outcome measures in patients with musculoskeletal impairments related to the spine?: A 'trustworthy' systematic review and meta-analysis.The Journal of manual & manipulative therapy · 2024Pooled it
- Effectiveness of cervicothoracic and thoracic manual physical therapy in managing upper quarter disorders - a systematic review.The Journal of manual & manipulative therapy · 2022Pooled it
- Myofascial Release for Chronic Low Back Pain: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2019Pooled it
- Manipulation-induced hypoalgesia in musculoskeletal pain populations: a systematic critical review and meta-analysis.Chiropractic & manual therapies · 2019Pooled it
- The regional effect of spinal manipulation on the pressure pain threshold in asymptomatic subjects: a systematic literature review.Chiropractic & manual therapies · 2018Pooled it
- Supported biopsychosocial self-management for back-related leg pain: a randomized feasibility study integrating a whole person perspective.Chiropractic & manual therapies · 2025Trial
- Exploring the immediate and short-term effect of lumbar spinal manipulation on pressure pain threshold: a randomized controlled trial of healthy participants.Chiropractic & manual therapies · 2024Trial
- Effects of exercise combined with cervicothoracic spine self-mobilization on chronic non-specific neck pain.Scientific reports · 2024Trial
- Expectations affect pain sensitivity changes during massage.The Journal of manual & manipulative therapy · 2023Trial
- The Immediate Effect of Adding Lumbar Mobilization to A Static Stretching Program on Hamstrings Range of Motion: An Exploratory Study.Journal of sports science & medicine · 2022Trial
- Effectiveness of local exercise therapy versus spinal manual therapy in patients with patellofemoral pain syndrome: medium term follow-up results of a randomized controlled trial.BMC musculoskeletal disorders · 2021Trial
- Spinal manipulation and modulation of pain sensitivity in persistent low back pain: a secondary cluster analysis of a randomized trial.Chiropractic & manual therapies · 2021Trial
- Changes in pain sensitivity and spinal stiffness in relation to responder status following spinal manipulative therapy in chronic low Back pain: a secondary explorative analysis of a randomized trial.BMC musculoskeletal disorders · 2021Trial
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Spinal manipulation (SMT) is commonly used for treating individuals experiencing musculoskeletal pain. The mechanisms of SMT remain unclear; however, pain sensitivity testing may provide insight into these mechanisms. The purpose of this systematic review is to examine the literature on the hypoalgesic effects of SMT on pain sensitivity measures and to quantify these effects using meta-analysis. We performed a systematic search of articles using CINAHL, MEDLINE, PsycINFO, and SPORTDiscus from each databases' inception until May 2011. We examined methodological quality of each study and generated pooled effect size estimates using meta-analysis software. Of 997 articles identified, 20 met inclusion criteria for this review. Pain sensitivity testing used in these studies included chemical, electrical, mechanical, and thermal stimuli applied to various anatomical locations. Meta-analysis was appropriate for studies examining the immediate effect of SMT on mechanical pressure pain threshold (PPT). SMT demonstrated a favorable effect over other interventions on increasing PPT. Subgroup analysis showed a significant effect of SMT on increasing PPT at the remote sites of stimulus application supporting a potential central nervous system mechanism. Future studies of SMT related hypoalgesia should include multiple experimental stimuli and test at multiple anatomical sites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.