ArticleDevelopment (Cambridge, England)2012
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- An ultrastructural map of a spinal sensorimotor circuit reveals the potential of astroglia modulation.Cell reports · 2026Article
- The Roles of the Membrane-Anchored Glycoprotein RECK in Animal Development, Tumor Suppression, and Beyond.Life (Basel, Switzerland) · 2026Review
- Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages.Pigment cell & melanoma research · 2025Article
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- Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level.iScience · 2023Article
- The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1Nature neuroscience · 2022Article
- A Subset of Oligodendrocyte Lineage Cells Interact With the Developing Dorsal Root Entry Zone During Its Genesis.Frontiers in cellular neuroscience · 2022Article
- A Novel Lysolecithin Model for Visualizing DamageFrontiers in cell and developmental biology · 2021Article
- Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure.Development (Cambridge, England) · 2020Article
- Neural crest development: insights from the zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Modulation of RECK levels inJournal of biological research (Thessalonike, Greece) · 2019Article
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- The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones.Cell reports · 2019Article
- Microglia exit the CNS in spinal root avulsion.PLoS biology · 2019Article
- Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.Neural development · 2018Article
- Identification ofOncotarget · 2018Article
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- Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells.PLoS biology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The neural crest is a migratory, multipotent cell lineage that contributes to myriad tissues, including sensory neurons and glia of the dorsal root ganglia (DRG). To identify genes affecting cell fate specification in neural crest, we performed a forward genetic screen for mutations causing DRG deficiencies in zebrafish. This screen yielded a mutant lacking all DRG, which we named sensory deprived (sdp). We identified a total of four alleles of sdp, all of which possess lesions in the gene coding for reversion-inducing cysteine-rich protein containing Kazal motifs (Reck). Reck is an inhibitor of metalloproteinases previously shown to regulate cell motility. We found reck function to be both necessary for DRG formation and sufficient to rescue the sdp phenotype. reck is expressed in neural crest cells and is required in a cell-autonomous fashion for appropriate sensory neuron formation. In the absence of reck function, sensory neuron precursors fail to migrate to the position of the DRG, suggesting that this molecule is crucial for proper migration and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.