ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2012
Organ specific mapping of in vivo redox state in control and cigarette smoke-exposed mice using EPR/NMR co-imaging.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Tobacco cigarette smoking induces cerebrovascular dysfunction followed by oxidative neuronal injury with the onset of cognitive impairment.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Oxidative Stress and Age-Related Tumors.Antioxidants (Basel, Switzerland) · 2024Review
- Imaging Reactive Oxygen Radicals in Excised Mouse Lung Trapped by Reaction with Hydroxylamine Probes Using 1 GHz Rapid Scan Electron Paramagnetic Resonance.Molecular imaging and biology · 2024Article
- Quantum Mimicry With Inorganic Chemistry.Comments on modern chemistry. Part A, Comments on inorganic chemistry : a journal of critical discussion of the current literature · 2024Article
- Pathological mechanisms of cigarette smoking, dietary, and sedentary lifestyle risks in vascular dysfunction: mitochondria as a common target of risk factors.Pflugers Archiv : European journal of physiology · 2023Review
- Imaging analysis for multiple paramagnetic agents using OMRI and electrophoresis.Journal of clinical biochemistry and nutrition · 2022Article
- Ligand design of zero-field splitting in trigonal prismatic Ni(II) cage complexes.Dalton transactions (Cambridge, England : 2003) · 2022Article
- Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging.Antioxidants & redox signaling · 2022Article
- Ligand control of low-frequency electron paramagnetic resonance linewidth in Cr(III) complexes.Dalton transactions (Cambridge, England : 2003) · 2021Article
- Merging Preclinical EPR Tomography with other Imaging Techniques.Cell biochemistry and biophysics · 2019Article
- Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging.Metallomics : integrated biometal science · 2019Review
- Effects of oxygen challenging to tissue redox and pOFree radical biology & medicine · 2019Article
- The role of cellular reactive oxygen species in cancer chemotherapy.Journal of experimental & clinical cancer research : CR · 2018Review
- Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques.Redox biology · 2016Review
- Imaging Reactive Oxygen Species-Induced Modifications in Living Systems.Antioxidants & redox signaling · 2016Review
- Use of rapid-scan EPR to improve detection sensitivity for spin-trapped radicals.Biophysical journal · 2013Article
- In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model.Diabetes · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
In vivo mapping of alterations in redox status is important for understanding organ specific pathology and disease. While electron paramagnetic resonance imaging (EPRI) enables spatial mapping of free radicals, it does not provide anatomic visualization of the body. Proton MRI is well suited to provide anatomical visualization. We applied EPR/NMR co-imaging instrumentation to map and monitor the redox state of living mice under normal or oxidative stress conditions induced by secondhand cigarette smoke (SHS) exposure. A hybrid co-imaging instrument, EPRI (1.2 GHz)/proton MRI (16.18 MHz), suitable for whole-body co-imaging of mice was utilized with common magnet and gradients along with dual EPR/NMR resonators that enable co-imaging without sample movement. The metabolism of the nitroxide probe, 3-carbamoyl-proxyl (3-CP), was used to map the redox state of control and SHS-exposed mice. Co-imaging allowed precise 3D mapping of radical distribution and reduction in major organs such as the heart, lungs, liver, bladder and kidneys. Reductive metabolism was markedly decreased in SHS-exposed mice and EPR/NMR co-imaging allowed quantitative assessment of this throughout the body. Thus, in vivo EPR/NMR co-imaging enables in vivo organ specific mapping of free radical metabolism and redox stress and the alterations that occur in the pathogenesis of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.