ArticleBMC public health2012
Interaction between alcohol drinking and obesity in relation to colorectal cancer risk: a case-control study in Newfoundland and Labrador, Canada.
Article in BMC public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Meta-analysis of 16 studies of the association of alcohol with colorectal cancer.International journal of cancer · 2020Pooled it
- Socioeconomic differences in alcohol-attributable mortality compared with all-cause mortality: a systematic review and meta-analysis.International journal of epidemiology · 2014Pooled it
- Early-onset cancer and modifiable risk: quantifying the combined impact of excess body weight and alcohol on breast and colorectal cancer in Italy (18-34 years).BMC public health · 2026Article
- Diabetes and socioeconomic status as key risk factors for colorectal cancer in the pashtun population: a case-control study.BMC gastroenterology · 2026Article
- Non-preventable cases of breast, prostate, lung, and colorectal cancer in 2050 in an elimination scenario of modifiable risk factors.Scientific reports · 2024Article
- Biological factors driving colorectal cancer metastasis.World journal of gastrointestinal oncology · 2024Review
- Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy.BMC cancer · 2023Article
- Joint association of alcohol consumption and adiposity with alcohol- and obesity-related cancer in a population sample of 399,575 UK adults.The British journal of nutrition · 2023Article
- Body Mass Index and Other Risk Factors Effects on Colon Cancer Prognosis in Pakistan.Journal of cancer & allied specialties · 2022Article
- Colorectal Cancer Risk Factors and Screening Among the Uninsured of Tampa Bay: A Free Clinic Study.Preventing chronic disease · 2021Article
- Article
- Sociodemographics and their impacts on risk factor awareness and beliefs about cancer and screening: results from a cross-sectional study in Newfoundland and Labrador.BMC public health · 2020Article
- Alcohol Use and Gastrointestinal Cancer Risk.Visceral medicine · 2020Review
- Combined alcoholic and non-alcoholic steatohepatitis.JHEP reports : innovation in hepatology · 2020Review
- Trends in alcohol-related mortality by educational attainment in the U.S., 2000-2017.Population research and policy review · 2020Article
- Geographical patterns of the incidence and mortality of colorectal cancer in mainland Portugal municipalities (2007-2011).BMC cancer · 2019Article
- Article
- Review
- Effects of moderate alcohol consumption on gene expression related to colonic inflammation and antioxidant enzymes in rats.Alcohol (Fayetteville, N.Y.) · 2017Article
- Dietary patterns and colorectal cancer: results from a Canadian population-based study.Nutrition journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundWhile substantive epidemiological literature suggests that alcohol drinking and obesity are potential risk factors of colorectal cancer (CRC), the possible interaction between the two has not been adequately explored. We used a case-control study to examine if alcohol drinking is associated with an increased risk of CRC and if such risk differs in people with and without obesity.
methodsNewly diagnosed CRC cases were identified between 1999 and 2003 in Newfoundland and Labrador (NL). Cases were frequency-matched by age and sex with controls selected using random digit dialing. Cases (702) and controls (717) completed self-administered questionnaires assessing health and lifestyle variables. Estimates of alcohol intake included types of beverage, years of drinking, and average number of alcohol drinks per day. Odds ratios were estimated to investigate the associations of alcohol independently and when stratified by obesity status on the risk of CRC.
resultsAmong obese participants (BMI ≥ 30), alcohol was associated with higher risk of CRC (OR: 2.2; 95% CI: 1.2-4.0) relative to the non-alcohol category. Among obese individuals, 3 or more different types of drinks were associated with a 3.4-fold higher risk of CRC relative to non-drinkers. The risk of CRC also increased with drinking years and drinks daily among obese participants. However, no increased risk was observed in people without obesity.
conclusionThe effect of alcohol of drinking on CRC seems to be modified by obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.