ArticleBiology direct2012
Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen.
Article in Biology direct, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Energy metabolism and adaptation to hypoxia in the non-photosynthetic green alga Leontynka.BMC biology · 2026Article
- Untargeted GC-MS Metabolic Profiling of Anaerobic Gut Fungi Reveals Putative Terpenoids and Strain-Specific Metabolites.Metabolites · 2025Article
- Horizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote.Nature communications · 2025Article
- Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis.Fungal biology and biotechnology · 2021Article
- Article
- Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis.Scientific reports · 2021Article
- Origin and Evolution of Polycyclic Triterpene Synthesis.Molecular biology and evolution · 2020Article
- Reticulate evolution in eukaryotes: Origin and evolution of the nitrate assimilation pathway.PLoS genetics · 2019Article
- Bisnorgammacerane traces predatory pressure and the persistent rise of algal ecosystems after Snowball Earth.Nature communications · 2019Article
- Squalene Found in Alpine Grassland Soils under a Harsh Environment in the Tibetan Plateau, China.Biomolecules · 2018Article
- Novel Hydrogenosomes in the Microaerophilic Jakobid Stygiella incarcerata.Molecular biology and evolution · 2016Article
- Effects of soil erosion and anoxic-euxinic ocean in the Permian-Triassic marine crisis.Heliyon · 2016Article
- On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp. PC1.BMC biology · 2016Article
- A distinct pathway for tetrahymanol synthesis in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- On the age of eukaryotes: evaluating evidence from fossils and molecular clocks.Cold Spring Harbor perspectives in biology · 2014Review
- Evidence for a hydrogenosomal-type anaerobic ATP generation pathway in Acanthamoeba castellanii.PloS one · 2013Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Sterols are key components of eukaryotic cellular membranes that are synthesized by multi-enzyme pathways that require molecular oxygen. Because prokaryotes fundamentally lack sterols, it is unclear how the vast diversity of bacterivorous eukaryotes that inhabit hypoxic environments obtain, or synthesize, sterols. Here we show that tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments. Genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase were found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes.
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