ArticleJournal of inflammation (London, England)2012
Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema.
Article in Journal of inflammation (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges.Current pharmaceutical design · 2024Review
- The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs.Veterinary sciences · 2021Article
- Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation.Oxidative medicine and cellular longevity · 2021Article
- The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers.BioMed research international · 2020Article
- Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.Molecular medicine reports · 2020Article
- Study on the Structure of Ginseng Glycopeptides with Anti-Inflammatory and Analgesic Activity.Molecules (Basel, Switzerland) · 2018Article
- Antibacterial and anti-inflammatory activities of marineResearch in pharmaceutical sciences · 2017Article
- Beyond muscles: The untapped potential of creatine.International immunopharmacology · 2016Review
- Effects of hydrogen-rich water on depressive-like behavior in mice.Scientific reports · 2016Article
- Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock.International journal of clinical and experimental medicine · 2015Article
- Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.Medical gas research · 2015Article
- In vitro inflammation inhibition model based on semi-continuous toll-like receptor biosensing.PloS one · 2014Article
- A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.Medical gas research · 2014Review
- Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.Molecular and cellular biochemistry · 2013Article
- Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.International journal of ophthalmology · 2013Article
- The production of high dose hydrogen gas by the AMS-H-01 for treatment of disease.Medical gas researchArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress is thought to play an important role in the pathogenesis of inflammation. Recent studies have found that hydrogen gas has the effect of eliminating free radicals. Whether hydrogen saline (more convenient to be used than hydrogen gas) has the anti-inflammation effect or not is still unknown.
methodsCarrageenan-induced paw oedema and LPS-activated macrophages are studied in this article. Injection of carrageenan into the foot of a mouse elicited an acute inflammatory response characterized by increase of foot volume and infiltration of neutrophils. While tumor necrosis factorα(TNF-α) secreted by activated macrophages was determined by ELISA and real-time PCR.
resultsAll parameters of inflammation (foot volume, infiltration of neutrophils, amount of TNF-α and the level of TNF-α's mRNA) were attenuated by the hydrogen saline treatment.
conclusionAs a more convenient way than inhaling H2, hydrogen saline exhibits a protective effect against inflammation and it might provide a novel therapeutic approach for inflammatory diseases.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.