ArticleRespiratory research2012
Relationship between body composition, inflammation and lung function in overweight and obese asthma.
Article in Respiratory research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Comparison of physical activity, sedentary time, and physical fitness among Chinese children and adolescents in Qinghai between 2019 and 2023.Scientific reports · 2025Article
- Exploring the Asthma - Obesity Link Using Advanced Imaging Techniques.Physiological research · 2025Review
- Sex Differences in Lung Function in Asthma Across the Ages.CHEST pulmonary · 2024Article
- Dietary antioxidants and flavonoids intake, and their association with inflammation and oxidative stress parameters in asthmatic women: a case-control study.Journal of clinical biochemistry and nutrition · 2024Article
- Uncontrolled asthma is Associated with Increased Visceral Adipose Tissue, Decreased Bone Mineral Content, and Reduced Exercise Capacity.Journal of asthma and allergy · 2024Article
- The associations between body composition and vital capacity index of medical students in Shenyang of China: a cross-sectional survey.BMC pulmonary medicine · 2022Article
- Regional Fat Distributions Are Associated With Subclinical Right Ventricular Dysfunction in Adults With Uncomplicated Obesity.Frontiers in cardiovascular medicine · 2022Article
- Are wheezing, asthma and eczema in children associated with mother's health during pregnancy? Evidence from an Australian birth cohort.Archives of public health = Archives belges de sante publique · 2021Article
- Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities.The World Allergy Organization journal · 2020Article
- Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic.Journal of clinical medicine · 2020Review
- Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis.International journal of obesity (2005) · 2019Article
- Body composition from 18 to 22 years and pulmonary function at 22 years-1993 Pelotas Birth Cohort.PloS one · 2019Article
- Adiposity and Asthma in a Nationwide Study of Children and Adults in the United States.Annals of the American Thoracic Society · 2018Article
- Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort.BMC pulmonary medicine · 2017Article
- Screen-based sedentary behavior during adolescence and pulmonary function in a birth cohort.The international journal of behavioral nutrition and physical activity · 2017Article
- Long-term exposure to diesel engine exhaust induced lung function decline in a cross sectional study.Industrial health · 2017Article
- Establishing failure predictors for the planned extubation of overweight and obese patients.PloS one · 2017Article
- Reply: What About Neutrophils in Obese Asthma?American journal of respiratory cell and molecular biology · 2016Article
- Relationships among obesity, physical activity and sedentary behavior in young adolescents with and without lifetime asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Article
- Alterations in Lung Functions Based on BMI and Body Fat % Among Obese Indian Population at National Capital Region.Nepal journal of epidemiology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma.
methodsOverweight and obese (BMI 28-40 kg/m(2)) adults with asthma (n = 44) completed lung function assessment and underwent full-body dual energy x-ray absorptiometry. Venous blood samples and induced sputum were analysed for inflammatory markers.
resultsIn females, android and thoracic fat tissue and total body lean tissue were inversely correlated with expiratory reserve volume (ERV). Conversely in males, fat tissue was not correlated with lung function, however there was a positive association between android and thoracic lean tissue and ERV. Lower body (gynoid and leg) lean tissue was positively associated with sputum %neutrophils in females, while leptin was positively associated with android and thoracic fat tissue in males.
conclusionsThis study suggests that both body composition and inflammation independently affect lung function, with distinct differences between males and females. Lean tissue exacerbates the obese-asthma phenotype in females and the mechanism responsible for this finding warrants further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.