ArticleVeterinary research2012
Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Incomplete protection of the KVeterinary research · 2026Article
- Silent Propagation of Classical Scrapie Prions in Homozygous KEmerging infectious diseases · 2025Article
- First Report of Polymorphisms and Genetic Characteristics ofAnimals : an open access journal from MDPI · 2024Article
- National Prevalence of Caprine Prion Protein Genetic Variability at Codons 146, 211, and 222 in Goat Herds in the United States.Veterinary sciences · 2023Article
- The first report of polymorphisms of the prion protein gene (Frontiers in veterinary science · 2023Article
- Article
- Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPGenetics, selection, evolution : GSE · 2021Article
- Genetic Variation in the Prion Protein Gene (Animals : an open access journal from MDPI · 2021Article
- White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains.Scientific reports · 2021Article
- Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases.Animals : an open access journal from MDPI · 2021Review
- Article
- Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States.PloS one · 2021Article
- Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.Scientific reports · 2020Article
- PRNP gene polymorphisms in main indigenous Turkish goat breeds.Tropical animal health and production · 2020Article
- Goats naturally devoid of PrPVeterinary research · 2020Article
- Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protective variant in native Ethiopian goats.BMC veterinary research · 2019Article
- Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats.Veterinary research · 2018Article
- Genetic profile of scrapie codons 146, 211 and 222 in the PRNP gene locus in three breeds of dairy goats.PloS one · 2018Article
- Clinical, pathological, and molecular features of classical and L-type atypical-BSE in goats.PloS one · 2018Article
- Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP). Breeding programs have been implemented to increase scrapie resistance in sheep populations; though desirable, a similar approach has not yet been applied in goats. European studies have now suggested that several polymorphisms can modulate scrapie susceptibility in goats: in particular, PRNP variant K222 has been associated with resistance in case-control studies in Italy, France and Greece. In this study we investigated the resistance conferred by this variant using a natural Italian goat scrapie isolate to intracerebrally challenge five goats carrying genotype Q/Q 222 (wild type) and five goats carrying genotype Q/K 222. By the end of the study, all five Q/Q 222 goats had died of scrapie after a mean incubation period of 19 months; one of the five Q/K 222 goats died after 24 months, while the other four were alive and apparently healthy up to the end of the study at 4.5 years post-challenge. All five of these animals were found to be scrapie negative. Statistical analysis showed that the probability of survival of the Q/K 222 goats versus the Q/Q 222 goats was significantly higher (p = 0.002). Our study shows that PRNP gene mutation K222 is strongly associated with resistance to classical scrapie also in experimental conditions, making it a potentially positive target for selection in the frame of breeding programs for resistance to classical scrapie in goats.
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