Evidence map›Paper›PMID 22296574›Full record

ArticleJournal of the American Chemical Society2012

Model system for cell adhesion mediated by weak carbohydrate-carbohydrate interactions.

Bärbel Lorenz, Luis Álvarez de Cienfuegos, Marieelen Oelkers, Ella Kriemen, Christian Brand, Milena Stephan, Eva Sunnick, Deniz Yüksel, Venkateshwarlu Kalsani, Krishna Kumar and 2 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Glyconectin Cell Adhesion Epitope, β-d-GlcMolecules (Basel, Switzerland) · 2021
    Article
  5. Membrane fusion studied by colloidal probes.European biophysics journal : EBJ · 2021
    Review
  6. Review
  7. Interplay ofFrontiers in molecular biosciences · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Bärbel LorenzInstitute of Physical Chemistry, University of Göttingen, Tammannstrasse 6, 37077 Göttingen, Germany.
Luis Álvarez de Cienfuegos
Marieelen Oelkers
Ella Kriemen
Christian Brand
Milena Stephan
Eva Sunnick
Deniz Yüksel
Venkateshwarlu Kalsani
Krishna Kumar
Daniel B Werz
Andreas Janshoff
Tufts University · USUniversidad de Granada · ESUniversity of Göttingen · DE

Funding

Protein Design Using Unnatural Amino AcidsR01GM065500 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI KUMAR, KRISHNA · 2002 to 2010
$2.5M
Fluorinated Cell Surfaces to Modulate Biological FunctionR01CA125033 · NCI · TUFTS UNIVERSITY MEDFORD · PI KUMAR, KRISHNA · 2008 to 2011
$1.7M
NCI NIH HHS CA125033NCI NIH HHS R01 CA125033NIGMS NIH HHS GM065500NIGMS NIH HHS R01 GM065500
6 · The paper itself

Abstract

The multivalent carbohydrate-carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell-cell contacts.The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone.

Indexed as

AnimalsCell AdhesionDisaccharidesLipid BilayersMicroscopy, Scanning ProbePoriferaDisaccharidesLipid Bilayers

Identifiers

PMID22296574
PMCPMC3288207
OpenAlexW2323680020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.