Trial reportAging & mental health2012
Prognostic factors, course, and outcome of depression among older primary care patients: the PROSPECT study.
Trial report in Aging & mental health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Psychological resilience and depressive symptoms among family caregivers of disabled people: the mediating role of caregiver burden and the moderating role of family functioning.Frontiers in psychology · 2026Article
- Transdiagnostic and functional predictors of depression severity and trajectory in the Penn state psychiatry clinical assessment and rating evaluation system (PCARES) registry.Journal of affective disorders · 2022Article
- Trajectories of major depression in middle-aged and older adults: A population-based study.International journal of geriatric psychiatry · 2019Article
- The two-year course of late-life depression; results from the Netherlands study of depression in older persons.BMC psychiatry · 2015Article
- The economic, public health, and caregiver burden of late-life depression.The Psychiatric clinics of North America · 2013Review
- Course, risk factors, and prognostic factors in elderly primary care patients with mild depression: a two-year observational study.Scandinavian journal of primary health care · 2013Article
- Chronic medical conditions and reproducibility of self-reported age at menopause among community-dwelling women.Menopause (New York, N.Y.) · 2011Article
- Integrated Care Models for Older Adults with Depression and Physical Comorbidity: A Scoping Review.International journal of integrated careArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesWe sought to examine whether there are patterns of evolving depression symptoms among older primary care patients that are related to prognostic factors and long-term clinical outcomes.
methodPrimary care practices were randomly assigned to Usual Care or to an intervention consisting of a depression care manager offering algorithm-based depression care. In all, 599 adults 60 years and older meeting criteria for major depression or clinically significant minor depression were randomly selected. Longitudinal analysis via growth curve mixture modeling was carried out to classify patients according to the patterns of depression symptoms across 12 months. Depression diagnosis determined after a structured interview at 24 months was the long-term clinical outcome.
resultsThree patterns of change in depression symptoms over 12 months were identified: high persistent course (19.1% of the sample), high declining course (14.4% of the sample), and low declining course (66.5% of the sample). Being in the intervention condition was more likely to be associated with a course of high and declining depression symptoms than high and persistent depression symptoms (OR = 2.53, 95% CI [1.01, 6.37]). Patients with a course of high and persistent depression symptoms were much more likely to have a diagnosis of major depression at 24 months compared with patients with a course of low and declining depression symptoms (adjusted OR = 16.46, 95% CI [7.75, 34.95]).
conclusionIdentification of patients at particularly high risk of persistent depression symptoms and poor long-term clinical outcomes is important for the development and delivery of interventions.
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