Evidence map›Paper›PMID 22296405›Full record

ArticleJournal of the American Chemical Society2012

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.

Amit Gangar, Adrian Fegan, Sidath C Kumarapperuma, Carston R Wagner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Simultaneous dual protein labeling using a triorthogonal reagent.Journal of the American Chemical Society · 2013
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amit GangarDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Adrian Fegan
Sidath C Kumarapperuma
Carston R Wagner
University of Minnesota · US

Funding

Chemically Controlled Assembly of Therapuetic Protein NanostrcturesR01CA120116 · NCI · UNIVERSITY OF MINNESOTA · PI WAGNER, CARSTON R. · 2007 to 2010
$1.2M
Self-Assemblying Immunotherapeutic NanoringsR01CA125360 · NCI · UNIVERSITY OF MINNESOTA · PI WAGNER, CARSTON R. · 2008 to 2011
$1.2M
NCI NIH HHS CA120116NCI NIH HHS CA125360NCI NIH HHS R01 CA120116NCI NIH HHS R01 CA125360
6 · The paper itself

Abstract

Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

Indexed as

AntibodiesBoron CompoundsCarrier ProteinsCD3 ComplexCell Line, TumorChromatographyDimerizationDiphosphonatesFlow CytometryHumansLigandsMethotrexateModels, ChemicalOligonucleotidesProteinsSingle-Chain Antibodies4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAntibodiesBoron CompoundsCarrier ProteinsCD3 ComplexDiphosphonatesLigandsMethotrexatemethotrexate bisphosphonateOligonucleotidesProteinsSingle-Chain AntibodiesTetrahydrofolate Dehydrogenase

Identifiers

PMID22296405
PMCPMC3312035
OpenAlexW2038940704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.