ArticleTissue antigens2012
Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma.
Article in Tissue antigens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A meta-analysis of genome-wide association studies of follicular lymphoma.BMC genomics · 2012Pooled it
- Genetic variation in IL-6 rs1800796 and its association with non-Hodgkin lymphoma susceptibility in the Egyptian population.Journal of biosciences · 2026Article
- High-resolution HLA class II sequencing of Swedish multiple sclerosis patients.International journal of immunogenetics · 2022Article
- Identification of 8-Digit HLA-A, -B, -C, and -DRB1 Allele and Haplotype Frequencies in Koreans Using the One Lambda AllType Next-Generation Sequencing Kit.Annals of laboratory medicine · 2021Article
- Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin's Lymphomas from Genome-Wide Association Studies.International journal of molecular sciences · 2020Review
- Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.Cancer causes & control : CCC · 2020Article
- Pro-inflammatory dopamine-2 receptor-specific T cells in paediatric movement and psychiatric disorders.Clinical & translational immunology · 2020Article
- The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population.Leukemia & lymphoma · 2019Article
- SNP variants associated with non-Hodgkin lymphoma (NHL) correlate with human leukocyte antigen (HLA) class II expression.Scientific reports · 2017Article
- NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study.PloS one · 2017Article
- Genetic barriers in transplantation medicine.World journal of transplantation · 2016Review
- Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells.Leukemia · 2016Review
- Reduced Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI).EBioMedicine · 2016Article
- Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating αβ T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients.Frontiers in immunology · 2016Article
- Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.American journal of human genetics · 2014Article
- Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression.Genes and immunity · 2014Article
- Genetic variation in the extended major histocompatibility complex and susceptibility to childhood acute lymphoblastic leukemia: a review of the evidence.Frontiers in oncology · 2013Review
- Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk.American journal of human genetics · 2013Article
- Integrating GWAS and expression data for functional characterization of disease-associated SNPs: an application to follicular lymphoma.American journal of human genetics · 2013Article
- Next-generation HLA sequencing using the 454 GS FLX system.Methods in molecular biology (Clifton, N.J.) · 2013Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Follicular lymphoma (FL) is an indolent, sometimes, fatal disease characterized by recurrence at progressively shorter intervals and is frequently refractive to therapy. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA) region on chromosome 6p21.32-33 that are statistically significantly associated with FL risk. Low to medium resolution typing of single or multiple HLA genes has provided an incomplete picture of the total genetic risk imparted by this highly variable region. To gain further insight into the role of HLA alleles in lymphomagenesis and to investigate the independence of validated SNPs and HLA alleles with FL risk, high-resolution HLA typing was conducted using next-generation sequencing in 222 non-Hispanic White FL cases and 220 matched controls from a larger San Francisco Bay Area population-based case-control study of lymphoma. A novel protective association was found between the DPB1*03:01 allele and FL risk [odds ratio (OR) = 0.39, 95% confidence interval (CI) = 0.21-0.68]. Extended haplotypes DRB1*01:01-DQA1*01:01-DQB1*05:01 (OR = 2.01, 95% CI = 1.22-3.38) and DRB1*15-DQA1*01-DQB1*06 (OR = 0.55, 95% CI = 0.36-0.82) also influenced FL risk. Moreover, DRB1*15-DQA1*01-DQB1*06 was highly correlated with an established FL risk locus, rs2647012. These results provide further insight into the critical roles of HLA alleles and SNPs in FL pathogenesis that involve multi-locus effects across the HLA region.
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