ArticleInternational journal of breast cancer2011
CXCR4 and axillary lymph nodes: review of a potential biomarker for breast cancer metastasis.
Article in International journal of breast cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer.Drug design, development and therapy · 2015Pooled it
- Clinicopathological significance of CXCR4 in non-small cell lung cancer.Drug design, development and therapy · 2015Pooled it
- Axillary metastasis in non-specific molecular profile of endometrial carcinoma: a case report and literature review.International journal of surgery case reports · 2026Article
- Ex Vivo Model of Breast Cancer Cell Invasion in Live Lymph Node Tissue.ACS pharmacology & translational science · 2025Article
- Could circulating tumor cells explain why breast conservation improves survival despite higher locoregional recurrence?Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Article
- Ex vivo model of breast cancer cell invasion in live lymph node tissue.bioRxiv : the preprint server for biology · 2024Article
- Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage.Nature communications · 2023Article
- Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Potential anticancer effect of prostratin through SIK3 inhibition.Oncology letters · 2018Article
- Effects of the ninein-like protein centrosomal protein on breast cancer cell invasion and migration.Molecular medicine reports · 2015Article
- Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells.Medical oncology (Northwood, London, England) · 2015Article
- Chemokine (C-X-C motif) receptor 4 RNA interference inhibits bone metastasis in breast cancer.Oncology letters · 2014Article
- In vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4.AIDS research and therapy · 2013Article
- The janus face of lipids in human breast cancer: how polyunsaturated Fatty acids affect tumor cell hallmarks.International journal of breast cancer · 2012Article
- USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer.Cancer journal (Sudbury, Mass.)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including the axillary lymph nodes. Axillary lymph nodes positive for breast carcinoma have been an important component of breast cancer diagnosis, treatment, and subsequent research. The goal of this paper is to analyze the literature that has explained the pathways from CXCR4 expression to breast cancer metastasis of the lymph nodes and the prognostic and/or predictive implications of lymph node metastases in the presence of elevated CXCR4.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.