ArticlePloS one2012
The kinetics of early T and B cell immune recovery after bone marrow transplantation in RAG-2-deficient SCID patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Investigating concomitant RAG-2 and LRBA mutations in SCID and autoimmunity.Clinical and experimental immunology · 2026Article
- A novel mutation in FNIP1 associated with a syndromic immunodeficiency and cardiomyopathy.Immunogenetics · 2024Article
- Can T-cell and B-cell excision circles predict development of inhibitors in pediatric hemophilia A?Pediatric research · 2023Article
- SLP76 Mutation Associated with Combined Immunodeficiency and EBV-Related Lymphoma.Journal of clinical immunology · 2023Article
- Multiplex HDR for disease and correction modeling of SCID by CRISPR genome editing in human HSPCs.Molecular therapy. Nucleic acids · 2023Article
- Poor T-cell receptor β repertoire diversity early posttransplant for severe combined immunodeficiency predicts failure of immune reconstitution.The Journal of allergy and clinical immunology · 2022Article
- Immune function in newborns withFrontiers in pediatrics · 2022Article
- Immune and TRG repertoire signature of the thymus in Down syndrome patients.Pediatric research · 2021Article
- Atypical immune phenotype in severe combined immunodeficiency patients with novel mutations in IL2RG and JAK3.Genes and immunity · 2020Article
- Central Immune Tolerance of T and B Cells in Patients With Idiopathic Hypoparathyroidism, T1D, and Autoimmune Thyroiditis.Journal of the Endocrine Society · 2019Article
- Immune reconstitution after HSCT in SCID-a cohort of conditioned and unconditioned patients.Immunologic research · 2019Article
- The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.Pediatric pulmonology · 2019Article
- Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.Journal of clinical immunology · 2018Article
- MHC II deficient infant identified by newborn screening program for SCID.Immunologic research · 2018Article
- Elevated IgM levels as a marker for a unique phenotype in patients with Ataxia telangiectasia.BMC pediatrics · 2018Article
- TJournal of clinical immunology · 2018Article
- Diagnostic Tools for Inborn Errors of Human Immunity (Primary Immunodeficiencies and Immune Dysregulatory Diseases).Current allergy and asthma reports · 2018Review
- T and B cell clonal expansion in Ras-associated lymphoproliferative disease (RALD) as revealed by next-generation sequencing.Clinical and experimental immunology · 2017Article
- Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs.Journal of translational medicine · 2017Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of T and B cell immune recovery after bone marrow transplantation (BMT) is affected by many pre- and post-transplant factors. Because of the profoundly depleted baseline T and B cell immunity in recombination activating gene 2 (RAG-2)-deficient severe combined immunodeficiency (SCID) patients, some of these factors are eliminated, and the immune recovery after BMT can then be clearly assessed. This process was followed in ten SCID patients in parallel to their associated transplant-related complications. Early peripheral presence of T and B cells was observed in 8 and 4 patients, respectively. The latter correlated with pre-transplant conditioning therapy. Cells from these patients carried mainly signal joint DNA episomes, indicative of newly derived B and T cells. They were present before the normalization of the T cell receptor (TCR) and the B cell receptor (BCR) repertoire. Early presentation of the ordered TCR gene rearrangements after BMT occurred simultaneously, but this pattern was heterogeneous over time, suggesting different and individual thymic recovery processes. Our findings early after transplant could suggest the long-term patients' clinical outcome. Early peripheral presence of newly produced B and T lymphocytes from their production and maturation sites after BMT suggests donor stem cell origin rather than peripheral expansion, and is indicative of successful outcome. Peripheral detection of TCR excision circles and kappa-deleting recombination excision circles in RAG-2-deficient SCID post-BMT are early markers of T and B cell reconstitution, and can be used to monitor outcome and tailor specific therapy for patients undergoing BMT.
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