Evidence map›Paper›PMID 22294849›Full record

ArticleThe Journal of manual & manipulative therapy2011

Placebo response to manual therapy: something out of nothing?

Joel E Bialosky, Mark D Bishop, Steven Z George, Michael E Robinson

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of manual & manipulative therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02396550 nacompletednot on this mapstarted 2015, after this paper: background citation

Influence of Patient Expectations With Lateral Epicondylalgia in Applying Mobilization With Movement. Clinical Trial

TypeinterventionalSponsorUniversity of AlcalaRan2015 to 2016Enrolled66ConditionsTennis ElbowArmsPositive Expectations, Mobilization with movement
NCT03017534 nacompletednot on this mapstarted 2017, after this paper: background citation

Non-Specific Effects of Manual Therapy: A Mixed-Methods Investigation of Contextual and Social Interactions

TypeinterventionalSponsorShenandoah UniversityRan2017 to 2017Enrolled24ConditionsMusculoskeletal Manipulations, Placebo EffectArmsSpinal Manual Therapy
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.

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  18. State of the art: What have the pain sciences brought to physiotherapy?The South African journal of physiotherapy · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joel E BialoskyDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Mark D Bishop
Steven Z George
Michael E Robinson
University of Florida · US

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
NICHD NIH HHS K12 HD055929
6 · The paper itself

Abstract

The mechanisms through which manual therapy inhibits musculoskeletal pain are likely multifaceted and related to the interaction between the intervention, the patient, the practitioner, and the environment. Placebo is traditionally considered an inert intervention; however, the pain research literature suggests that placebo is an active hypoalgesic agent. Placebo response likely plays a role in all interventions for pain and we suggest that the same is true for the treatment effects associated with manual therapy. The magnitude of a placebo response may be influenced by negative mood, expectation, and conditioning. We suggest that manual therapists conceptualize placebo not only as a comparative intervention, but also as a potential active mechanism to partially account for treatment effects associated with manual therapy. We are not suggesting manual therapists include known sham or ineffective interventions in their clinical practice, but take steps to maximize placebo responses to reduce pain.

Indexed as

Manual therapyPainPlacebo

Identifiers

PMID22294849
PMCPMC3172952
OpenAlexW2159886936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.