ArticleWorld journal of gastroenterology2012
Population-based study of DNA image cytometry as screening method for esophageal cancer.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Spatial ploidy inference using quantitative imaging.Cell reports methods · 2025Article
- DNA aneuploidy combined with radial EBUS in the diagnosis of peripheral lung lesions.Diagnostic cytopathology · 2022Article
- Calibration-Aimed Comparison of Image-Cytometry- and Flow-Cytometry-Based Approaches of Ploidy Analysis.Sensors (Basel, Switzerland) · 2022Article
- Plasma Metabolomics Reveals Diagnostic Biomarkers and Risk Factors for Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Serum metabolomics analysis for the progression of esophageal squamous cell carcinoma.Journal of Cancer · 2021Article
- Value of automatic DNA image cytometry for diagnosing lung cancer.Oncology letters · 2018Article
- Identification of Serum MicroRNAs as Novel Biomarkers in Esophageal Squamous Cell Carcinoma Using Feature Selection Algorithms.Frontiers in oncology · 2018Article
- DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esophageal squamous precancerous lesions.
methodsThis study was designed as a population-based screening study. A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong. However, only 452 subjects had results of liquid-based cytology, DNA-ICM and pathology. The sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse.
resultsSensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%, 86.36%, 79.55% and 77.27%, respectively, which were better than that of liquid-based cytology (75%). Specificities of DNA-ICM were 70.83%, 84.07%, 92.65% and 96.81%, but the specificity of liquid-based cytology was 91.91%. The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%, respectively.
conclusionIt is possible to use DNA-ICM technique as a primary screening method for esophageal squamous precancerous lesions.
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