SynthesisWorld journal of gastroenterology2012
Present and future of prophylactic antibiotics for severe acute pancreatitis.
Synthesis in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Assessment of prophylactic antibiotics administration for acute pancreatitis: a meta-analysis of randomized controlled trials.Chinese medical journal · 2020Pooled it
- Pharmacological interventions for acute pancreatitis.The Cochrane database of systematic reviews · 2017Pooled it
- Role of antibiotic prophylaxis in necrotizing pancreatitis: a meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Pooled it
- Acute Pancreatitis and Diabetic Ketoacidosis: Special Considerations in Diagnosis and Management.Case reports in endocrinology · 2025Article
- Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Review
- Practical approach to acute pancreatitis: from diagnosis to the management of complications.Internal and emergency medicine · 2024Review
- Effect of early antibiotic treatment strategy on prognosis of acute pancreatitis.BMC gastroenterology · 2023Article
- Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate.Nutrients · 2023Article
- Role of the SARS‑COV2 infection in the evolution of acute pancreatitis (Review).Biomedical reports · 2023Review
- Investigation of antibiotic use in patients with acute pancreatitis in a Vietnamese hospital.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Antibacterial and Antifungal Therapy for Patients with Acute Pancreatitis at High Risk of Pancreatogenic Sepsis (Review).Sovremennye tekhnologii v meditsine · 2020Review
- 2019 WSES guidelines for the management of severe acute pancreatitis.World journal of emergency surgery : WJES · 2019Review
- Management of acute pancreatitis in the first 72 hours.Current opinion in gastroenterology · 2018Review
- The effect of non-steroidal anti-inflammatory drugs on severity of acute pancreatitis and pancreatic necrosis.Annals of the Royal College of Surgeons of England · 2018Article
- Prophylactic antibiotics in acute pancreatitis: endless debate.Annals of the Royal College of Surgeons of England · 2017Article
- Clinical practice guideline: management of acute pancreatitis.Canadian journal of surgery. Journal canadien de chirurgie · 2016Review
- Compliance with Evidence-Based Guidelines in Acute Pancreatitis: an Audit of Practices in University of Toronto Hospitals.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Management of Acute Pancreatitis in the Early Stage.Maedica · 2015Article
- Hepato-pancreato-biliary emergencies for the acute care surgeon: etiology, diagnosis and treatment.World journal of emergency surgery : WJES · 2015Article
- Antibiosis of Necrotizing Pancreatitis.Viszeralmedizin · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of prophylactic antibiotics in the reduction of mortality of severe acute pancreatitis (SAP) patients, which is highly questioned by more and more randomized controlled trials (RCTs) and meta-analyses.
methodsAn updated meta-analysis was performed. RCTs comparing prophylactic antibiotics for SAP with control or placebo were included for meta-analysis. The mortality outcomes were pooled for estimation, and re-pooled estimation was performed by the sensitivity analysis of an ideal large-scale RCT.
resultsCurrently available 11 RCTs were included. Subgroup analysis showed that there was significant reduction of mortality rate in the period before 2000, while no significant reduction in the period from 2000 [Risk Ratio, (RR) = 1.01, P = 0.98]. Funnel plot indicated that there might be apparent publication bias in the period before 2000. Sensitivity analysis showed that the RR of mortality rate ranged from 0.77 to 1.00 with a relatively narrow confidence interval (P < 0.05). However, the number needed to treat having a minor lower limit of the range (7-5096 patients) implied that certain SAP patients could still potentially prevent death by antibiotic prophylaxis.
conclusionCurrent evidences do not support prophylactic antibiotics as a routine treatment for SAP, but the potentially benefited sub-population requires further investigations.
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