ReviewSleep2012
A closed literature-based discovery technique finds a mechanistic link between hypogonadism and diminished sleep quality in aging men.
Review in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Associations of testosterone and cortisol concentrations with sleep quality in Japanese male workers.Comprehensive psychoneuroendocrinology · 2022Article
- Broad-coverage biomedical relation extraction with SemRep.BMC bioinformatics · 2020Article
- A systematic review on literature-based discovery workflow.PeerJ. Computer science · 2019Article
- Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing.Journal of biomedical semantics · 2018Article
- Biomedical text mining for research rigor and integrity: tasks, challenges, directions.Briefings in bioinformatics · 2018Article
- Rediscovering Don Swanson: the Past, Present and Future of Literature-Based Discovery.Journal of data and information science (Warsaw, Poland) · 2017Article
- Sortal anaphora resolution to enhance relation extraction from biomedical literature.BMC bioinformatics · 2016Article
- Classification-by-Analogy: Using Vector Representations of Implicit Relationships to Identify Plausibly Causal Drug/Side-effect Relationships.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2016Article
- Context-driven automatic subgraph creation for literature-based discovery.Journal of biomedical informatics · 2015Article
- Networks of neuroinjury semantic predications to identify biomarkers for mild traumatic brain injury.Journal of biomedical semantics · 2015Article
- A methodology for extending domain coverage in SemRep.Journal of biomedical informatics · 2013Article
- Extending SemRep to the Public Health Domain.Journal of the American Society for Information Science and Technology : JASIST · 2013Article
- A literature-based assessment of concept pairs as a measure of semantic relatedness.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2013Article
- Semantic MEDLINE for discovery browsing: using semantic predications and the literature-based discovery paradigm to elucidate a mechanism for the obesity paradox.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2013Article
- Automating case definitions using literature-based reasoning.Applied clinical informatics · 2013Article
- SemMedDB: a PubMed-scale repository of biomedical semantic predications.Bioinformatics (Oxford, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
STUDY
objectivesSleep quality commonly diminishes with age, and, further, aging men often exhibit a wider range of sleep pathologies than women. We used a freely available, web-based discovery technique (Semantic MEDLINE) supported by semantic relationships to automatically extract information from MEDLINE titles and abstracts.
designWe assumed that testosterone is associated with sleep (the A-C relationship in the paradigm) and looked for a mechanism to explain this association (B explanatory link) as a potential or partial mechanism underpinning the etiology of eroded sleep quality in aging men. MEASUREMENTS AND
resultsReview of full-text papers in critical nodes discovered in this manner resulted in the proposal that testosterone enhances sleep by inhibiting cortisol. Using this discovery method, we posit, and could confirm as a novel hypothesis, cortisol as part of a mechanistic link elucidating the observed correlation between decreased testosterone in aging men and diminished sleep quality.
conclusionsThis approach is publically available and useful not only in this manner but also to generate from the literature alternative explanatory models for observed experimental results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.