Evidence map›Paper›PMID 22294753›Full record

ReviewEndocrinology2012

Minireview: Glucagon in stress and energy homeostasis.

B J Jones, T Tan, S R Bloom

Open access · bronzeAbstract readReview
In one paragraph

Review in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Effect of GLP-1 receptor agonist on nutrient intake: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  6. Postprandial Glucagon Action in the Human Brain.Diabetes, obesity & metabolism · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Daily Brain Metabolic Rhythms of Wild Nocturnal Bats.International journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

B J JonesDepartment of Investigative Medicine, Commonwealth Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, United Kingdom.
T Tan
S R Bloom
Imperial College London · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G7811974
6 · The paper itself

Abstract

Glucagon is traditionally thought of as an antihypoglycemic hormone, for example in response to starvation. However, it actually increases energy expenditure and has other actions not in line with protection from hypoglycemia. Furthermore, it is often found to be elevated when glucose is also raised, for example in circumstances of psychological and metabolic stress. These findings seem more in keeping with glucagon having some role as a hormone enhancing the response to stress.

Indexed as

HomeostasisStress, PhysiologicalAnimalsEnergy MetabolismFeeding BehaviorGlucagonGlucoseHormonesHumansHypoglycemiaMetabolismModels, BiologicalObesityReceptors, GlucagonStress, PsychologicalGlucagonGlucoseHormonesReceptors, Glucagon

Identifiers

PMID22294753
PMCPMC3281544
OpenAlexW1998666715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.