ArticleAnnals of the rheumatic diseases2012
Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.
Article in Annals of the rheumatic diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.PloS one · 2013Pooled it
- Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet's disease patients: a preliminary report.Clinical rheumatology · 2024Article
- Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study.Pediatric rheumatology online journal · 2024Article
- Single Nucleotide Polymorphisms Associated with Rheumatoid Arthritis in Saudi Patients.Journal of clinical medicine · 2023Article
- Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.Clinical rheumatology · 2021Article
- Genetic aspects of idiopathic paediatric uveitis and juvenile idiopathic arthritis associated uveitis in Chinese Han.The British journal of ophthalmology · 2020Article
- Building a Population Representative Pediatric Biobank: Lessons Learned From the Greater Cincinnati Childhood Cohort.Frontiers in public health · 2020Article
- Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis.Journal of clinical medicine · 2019Article
- The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2018Article
- Single nucleotide polymorphism of Methyl-CpG-binding protein 2 gene associates with juvenile idiopathic arthritis.Clinical rheumatology · 2018Article
- Τhe genetics of juvenile idiopathic arthritis: Searching for new susceptibility loci.Molecular medicine reports · 2017Article
- A genome-wide association study of emotion dysregulation: Evidence for interleukin 2 receptor alpha.Journal of psychiatric research · 2016Article
- Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population.Pediatric rheumatology online journal · 2016Article
- Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.Genes and immunity · 2015Article
- Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt.Journal of immunology research · 2015Article
- The biologic basis of clinical heterogeneity in juvenile idiopathic arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Predisposition to Behçet's disease and VKH syndrome by genetic variants of miR-182.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Network analysis identifies protein clusters of functional importance in juvenile idiopathic arthritis.Arthritis research & therapy · 2014Article
- Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation.The Journal of experimental medicine · 2014Article
- Polyarticular juvenile idiopathic arthritis - epidemiology and management approaches.Clinical epidemiology · 2014Review
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesRheumatoid arthritis (RA) shares some similar clinical and pathological features with juvenile idiopathic arthritis (JIA); indeed, the strategy of investigating whether RA susceptibility loci also confer susceptibility to JIA has already proved highly successful in identifying novel JIA loci. A plethora of newly validated RA loci has been reported in the past year. Therefore, the aim of this study was to investigate these single nucleotide polymorphisms (SNP) to determine if they were also associated with JIA.
methodsThirty-four SNP that showed validated association with RA and had not been investigated previously in the UK JIA cohort were genotyped in JIA cases (n=1242), healthy controls (n=4281), and data were extracted for approximately 5380 UK Caucasian controls from the Wellcome Trust Case-Control Consortium 2. Genotype and allele frequencies were compared between cases with JIA and controls using PLINK. A replication cohort of 813 JIA cases and 3058 controls from the USA was available for validation of any significant findings.
resultsThirteen SNP showed significant association (p<0.05) with JIA and for all but one the direction of association was the same as in RA. Of the eight loci that were tested, three showed significant association in the US cohort.
conclusionsA novel JIA susceptibility locus was identified, CD247, which represents another JIA susceptibility gene whose protein product is important in T-cell activation and signalling. The authors have also confirmed association of the PTPN2 and IL2RA genes with JIA, both reaching genome-wide significance in the combined analysis.
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