ArticleSleep & breathing = Schlaf & Atmung2013
Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury.
Article in Sleep & breathing = Schlaf & Atmung, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- A systematic review on the association of sleep-disordered breathing with cardiovascular pathology in adults.NPJ primary care respiratory medicine · 2022Pooled it
- Association of obstructive sleep apnoea with the risk of vascular outcomes and all-cause mortality: a meta-analysis.BMJ open · 2017Pooled it
- Pooled it
- Pooled it
- Validation of the efficacy of the GPSS questionnaire for screening obstructive sleep apnea.Frontiers in medicine · 2025Article
- Prevalence and determinants of high-risk obstructive sleep apnea among hypertensive patients in referral hospitals of the Amhara Region, Northwest Ethiopia, 2022.Frontiers in sleep · 2025Article
- Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options.Translational stroke research · 2024Review
- Relationship Between Obstructive Sleep Apnea Severity and Serum Endocan Levels in Patients With Hypertension.Texas Heart Institute journal · 2023Article
- High-sensitivity cardiac troponin T in obstructive sleep apnea patients without cardiovascular diseases: Efficacy of CPAP treatment.Chronic respiratory disease · 2018Article
- The Link Between Obstructive Sleep Apnea and Cardiovascular Disease.Current atherosclerosis reports · 2016Review
- Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility.Biomarkers in medicine · 2016Review
- Validation of blood pressure monitoring using pulse transit time in heart failure patients with Cheyne-Stokes respiration undergoing adaptive servoventilation therapy.Sleep & breathing = Schlaf & Atmung · 2014Article
- A triple risk model for unexplained late stillbirth.BMC pregnancy and childbirth · 2014Article
- Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism.Sleep & breathing = Schlaf & Atmung · 2014Review
- Early left ventricular systolic and diastolic dysfunction in patients with newly diagnosed obstructive sleep apnoea and normal left ventricular ejection fraction.TheScientificWorldJournal · 2014Article
- Mortality in middle-aged men with obstructive sleep apnea in Finland.Sleep & breathing = Schlaf & Atmung · 2013Article
- Altered profile of circulating endothelial progenitor cells in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2013Article
- Acute sleep deprivation in healthy adults is associated with a reduction in left atrial early diastolic strain rate.Sleep & breathing = Schlaf & Atmung · 2013Article
- Death by a thousand cuts in Alzheimer's disease: hypoxia--the prodrome.Neurotoxicity research · 2013Review
- Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease.Neurochemical research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe hypothesized that obstructive sleep apnea(OSA) has a dose-dependent impact on mortality in those with ischemic heart disease or previous myocardial injury.
methodsWe performed a retrospective cohort study of 281 consecutive OSA patients with a history of myocardial injury as determined by elevated troponin levels or with known existing ischemic heart disease. We compared survival between those with severe OSA [apnea–hypopneaindex (AHI) ≥30] and those with mild to moderate OSA(AHI >5 and <30).
resultsOf the 281 patients (mean age 65 years, mean BMI34, 98% male, 58% with diabetes), 151 patients had mild moderate OSA and 130 had severe OSA. During a mean follow-up of 4.1 years, there were significantly greater deaths in the severe OSA group compared to the mild moderate OSA group [53 deaths (41%) vs. 44 deaths(29%), respectively, p00.04]. The adjusted hazard ratio for mortality with severe OSA was 1.72 (95% confidence interval1.01–2.91, p00.04).
conclusionsThe severity of obstructive sleep apnea is associated with increased risk of death, and risk stratification based on OSA severity is relevant even in the diseased cardiac patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.