ArticleMagnetic resonance in medicine2012
Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 114 citations in OpenAlex.
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- Comprehensive assessment of osteoporosis in lumbar spine using compositional MR imaging of trabecular bone.European radiology · 2023Article
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- Fast bound and pore water mapping of cortical bone with arbitrary slice oriented two-dimensional ultra-short echo time.Magnetic resonance in medicine · 2023Article
- Quantitative myelin water imaging using short TR adiabatic inversion recovery prepared echo-planar imaging (STAIR-EPI) sequence.Frontiers in radiology · 2023Article
- MRI-based porosity index (PI) and suppression ratio (SR) in the tibial cortex show significant differences between normal, osteopenic, and osteoporotic female subjects.Frontiers in endocrinology · 2023Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Myelin water imaging using a short-TR adiabatic inversion-recovery (STAIR) sequence.Magnetic resonance in medicine · 2022Article
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Advances in modern magnetic resonance imaging (MRI) pulse sequences have enabled clinically practical cortical bone imaging. Human cortical bone is known to contain a distribution of T(1) and T(2) components attributed to bound and pore water, although clinical imaging approaches have yet to discriminate bound from pore water based on their relaxation properties. Herein, two clinically compatible MRI strategies are proposed for selectively imaging either bound or pore water by utilizing differences in their T(1)s and T(2)s. The strategies are validated in a population of ex vivo human cortical bones, and estimates obtained for bound and pore water are compared to bone mechanical properties. Results show that the two MRI strategies provide good estimates of bound and pore water that correlate to bone mechanical properties. As such, the strategies for bound and pore water discrimination shown herein should provide diagnostically useful tools for assessing bone fracture risk, once applied to clinical MRI.
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