ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012
Evolution of the dynamic changes in functional cerebral oxidative metabolism from tissue mitochondria to blood oxygen.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Oxygen delivery and consumption in aging skeletal muscle: Insights from an electric analogy model of POPhysiological reports · 2026Article
- Mapping functional hemodynamic and metabolic responses to dementia: a broadband spectroscopy pilot study.Journal of biomedical optics · 2025Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Evaluation of calibrated and uncalibrated optical imaging approaches for relative cerebral oxygen metabolism measurements in awake mice.Physiological measurement · 2024Article
- High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Inhibitory Neuron Activity Contributions to Hemodynamic Responses and Metabolic Load Examined Using an Inhibitory Optogenetic Mouse Model.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface.Journal of neural engineering · 2018Article
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- Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex.Pflugers Archiv : European journal of physiology · 2017Article
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- Mitochondrial calcium homeostasis: Implications for neurovascular and neurometabolic coupling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Review
- Imaging of Neuronal Activity in Awake Mice by Measurements of Flavoprotein Autofluorescence Corrected for Cerebral Blood Flow.Frontiers in neuroscience · 2017Article
- Precision mapping of the vibrissa representation within murine primary somatosensory cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Understanding the dynamic relationship between cerebral blood flow and the BOLD signal: Implications for quantitative functional MRI.NeuroImage · 2015Article
- Neuronal and physiological correlation to hemodynamic resting-state fluctuations in health and disease.Brain connectivity · 2014Article
- Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates.NeuroImage · 2014Article
- The oxygen paradox of neurovascular coupling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow.Nature neuroscience · 2013Article
- Effects of the α₂-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex.The European journal of neuroscience · 2013Article
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3 authors at 1 institution in 1 country.
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Abstract
The dynamic properties of the cerebral metabolic rate of oxygen consumption (CMR(O2)) during changes in brain activity remain unclear. Therefore, the spatial and temporal evolution of functional increases in CMR(O2) was investigated in the rat somato-sensory cortex during forelimb stimulation under a suppressed blood flow response condition. Temporally, stimulation elicited a fast increase in tissue mitochondria CMR(O2) described by a time constant of ~1 second measured using flavoprotein autofluorescence imaging. CMR(O2)-driven changes in the tissue oxygen tension measured using an oxygen electrode and blood oxygenation measured using optical imaging of intrinsic signal followed; however, these changes were slow with time constants of ~5 and ~10 seconds, respectively. This slow change in CMR(O2)-driven blood oxygenation partly explains the commonly observed post-stimulus blood oxygen level-dependent (BOLD) undershoot. Spatially, the changes in mitochondria CMR(O2) were similar to the changes in blood oxygenation. Finally, the increases in CMR(O2) were well correlated with the evoked multi-unit spiking activity. These findings show that dynamic CMR(O2) calculations made using only blood oxygenation data (e.g., BOLD functional magnetic resonance imaging (fMRI)) do not directly reflect the temporal changes in the tissue's mitochondria metabolic rate; however, the findings presented can bridge the gap between the changes in cellular oxidative rate and blood oxygenation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.