ArticleCancer prevention research (Philadelphia, Pa.)2012
A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanisms.
Article in Cancer prevention research (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system.Frontiers in immunology · 2024Review
- Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammation.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2.Nutrients · 2020Article
- Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice.Oncotarget · 2020Article
- Preventive effects of Korean red ginseng on experimentally induced colitis and colon carcinogenesis.Journal of traditional and complementary medicine · 2020Article
- Pharmacokinetics of Panaxynol in Mice.Journal of cancer science and clinical therapeutics · 2020Article
- Apoptosis Exerts a Vital Role in the Treatment of Colitis-Associated Cancer by Herbal Medicine.Frontiers in pharmacology · 2020Review
- Phytochemical Modulation of MiRNAs in Colorectal Cancer.Medicines (Basel, Switzerland) · 2019Review
- Effects of compound K, an enteric microbiome metabolite of ginseng, in the treatment of inflammation associated colon cancer.Oncology letters · 2018Article
- Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds.Oncotarget · 2017Article
- Metabonomic Profiling Reveals Cancer Chemopreventive Effects of American Ginseng on Colon Carcinogenesis in Apc(Min/+) Mice.Journal of proteome research · 2015Article
- Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats.Scientific reports · 2015Article
- American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice.Journal of ginseng research · 2015Article
- Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.Journal of ethnopharmacology · 2015Article
- Inhibiting protein arginine deiminases has antioxidant consequences.The Journal of pharmacology and experimental therapeutics · 2015Article
- American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice.Journal of ginseng research · 2015Article
- Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model.Phytotherapy research : PTR · 2014Article
- Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats.PloS one · 2014Article
- A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng.PloS one · 2013Article
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11 authors at 3 institutions in 2 countries.
Funding
Abstract
Ulcerative colitis is a chronic inflammatory condition associated with a high colon cancer risk. We have previously reported that American ginseng extract significantly reduced the inflammatory parameters of chemically induced colitis. The aim of this study was to further delineate the components of American ginseng that suppress colitis and prevent colon cancer. Among five different fractions of American ginseng (butanol, hexane, ethylacetate, dichloromethane, and water), a hexane fraction has particularly potent antioxidant and proapoptotic properties. The effects of this fraction were shown in a mouse macrophage cell line (ANA-1 cells), in a human lymphoblastoid cell line (TK6), and in an ex vivo model (CD4(+)/CD25(-) primary effector T cells). A key in vivo finding was that compared with the whole American ginseng extract, the hexane fraction of American ginseng was more potent in treating colitis in a dextran sodium sulfate (DSS) mouse model, as well as suppressing azoxymethane/DSS-induced colon cancer. Furthermore, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) labeling of inflammatory cells within the colonic mesenteric lymph nodes was elevated in mice consuming DSS + the hexane fraction of American ginseng. Results are consistent with our in vitro data and with the hypothesis that the hexane fraction of American ginseng has anti-inflammatory properties and drives inflammatory cell apoptosis in vivo, providing a mechanism by which this fraction protects from colitis in this DSS mouse model. This study moves us closer to understanding the molecular components of American ginseng that suppress colitis and prevent colon cancer associated with colitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.