Trial reportEuropean journal of clinical nutrition2012
Effects of a novel propionate-rich sourdough bread on appetite and food intake.
Trial report in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Nutritional benefits of sourdoughs: A systematic review.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- The effects of SCFAs on glycemic control in humans: a systematic review and meta-analysis.The American journal of clinical nutrition · 2022Pooled it
- Sourdough Bread with Different Fermentation Times: A Randomized Clinical Trial in Subjects with Metabolic Syndrome.Nutrients · 2024Trial
- Acute effects of the food preservative propionic acid on glucose metabolism in humans.BMJ open diabetes research & care · 2021Trial
- Acute Effect of Resistant Starch on Food Intake, Appetite and Satiety in Overweight/Obese Males.Nutrients · 2018Trial
- Appetite and Subsequent Food Intake Were Unaffected by the Amount of Sourdough and Rye in Soft Bread-A Randomized Cross-Over Breakfast Study.Nutrients · 2018Trial
- Influence of the tolerability of vinegar as an oral source of short-chain fatty acids on appetite control and food intake.International journal of obesity (2005) · 2014Trial
- Effects of sourdough and yeast fermented breads consumption on glycaemia in healthy populations: a systematic review.Frontiers in nutrition · 2026Review
- Microencapsulated Propionate and Butyrate Improved Energy Balance and Gut Microbiota Composition in Diet-Induced Obese Rats.Nutrients · 2025Article
- Sourdough starter culture and breadmaking process impact wholemeal bread characteristics associated with starch digestibility.Current research in food science · 2025Article
- Effect of lactic acid-rich sourdough bread on appetite regulation: A randomized, double-blind controlled trial.Current research in food science · 2025Article
- Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling.Microbiome · 2022Observational
- The Intestinal Microbiota and Short-Chain Fatty Acids in Association with Advanced Metrics of Glycemia and Adiposity Among Young Adults with Type 1 Diabetes and Overweight or Obesity.Current developments in nutrition · 2022Article
- Propionate stimulates the secretion of satiety hormones and reduces acute appetite in a cecal fistula pig model.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation.Frontiers in cellular and infection microbiology · 2022Review
- Contribution of macronutrients to obesity: implications for precision nutrition.Nature reviews. Endocrinology · 2020Review
- Propionate and Alzheimer's Disease.Frontiers in aging neuroscience · 2020Review
- Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health.Current nutrition reports · 2018Review
- Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.Translational psychiatry · 2016Article
- Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.Microbial ecology in health and disease · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is evidence linking oral propionate to a reduction in food intake, which could confer functional food properties in the fight against obesity. However, propionate is typically volatile with a pungent smell and taste and so incorporating into foods naturally, at levels acceptable to the consumer is a novel approach. SUBJECTS/
methodsTwenty healthy, young, normal weight unrestrained eaters underwent an acute feeding study using a palatable sourdough and an identical control bread of a similar palatability, in a randomized cross-over balanced design for the assessment of appetite and energy intake.
resultsNo difference in energy intake of an ad libitum test meal, 180 min after the bread-based breakfast or in energy and macronutrient intake over the entire 24 h period was found between breads. Visual analogue scale ratings for appetite were not influenced by bread type, except the desire to eat something sweet. Elevated plasma insulin concentrations were observed following the propionate-rich sourdough breakfast (P=0.033 no effects of treatment on postprandial glycaemia were found.
conclusionsThese findings suggest propionate-rich sourdough bread does not influence appetite and food intake unlike larger doses of the food preservative N-propionate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.