ArticleBrain, behavior, and immunity2012
Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length.
Article in Brain, behavior, and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06732934 (The Effect of Basic Body Awareness Therapy and Aerobic Exercise Approaches on Telomere Length in Young Individuals), which is not on this map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Basic Body Awareness Therapy and Aerobic Exercise Approaches on Telomere Length in Young Individuals
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field.Brain, behavior, and immunity · 2016Pooled it
- A randomized controlled trial evaluating stress arousal reappraisal and worked example effects on psychophysiological responses during breaking bad news.Scientific reports · 2025Trial
- Internet-based stress management for distressed managers: results from a randomised controlled trial.Occupational and environmental medicine · 2018Trial
- Effect of Vitamin D3 Supplementation in Combination with Weight Loss on Inflammatory Biomarkers in Postmenopausal Women: A Randomized Controlled Trial.Cancer prevention research (Philadelphia, Pa.) · 2015Trial
- Dyslipidemia as a key nexus linking depression and aging acceleration: unraveling the mediating role of lipid accumulation product (LAP).European archives of psychiatry and clinical neuroscience · 2026Article
- A network analysis of lifetime stressor exposure, mental health, well-being, and immune cell mobilisation to acute stressors in young adults.Brain, behavior, & immunity - health · 2026Article
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways.Molecular cancer · 2025Review
- Why mindfulness matters in musculoskeletal therapies: a narrative review.Frontiers in psychology · 2025Review
- Article
- Compassionate Release: A Call to Social Workers.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2024Article
- Combined effects of cumulative stress and daily stressors on daily health.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Navigating Black Aging: The Biological Consequences of Stress and Depression.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Worse sleep, worsening post-traumatic stress disorder (PTSD): Poor sleep quality associated with increases in PTSD symptoms amongst those experiencing high threat of the COVID-19 pandemic.Journal of sleep research · 2022Article
- Changes in the expression of inflammatory and epigenetic-modulatory genes after an intensive meditation retreat.Comprehensive psychoneuroendocrinology · 2022Article
- Higher hair cortisol concentrations associated with shorter leukocyte telomere length in high-risk young adults.Scientific reports · 2022Article
- Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice.International journal of molecular sciences · 2022Article
- Telomeres and Psychological Stress: Perspective on Psychopathologies.Noro psikiyatri arsivi · 2022Review
- Article
- Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk.Frontiers in molecular neuroscience · 2021Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic psychological stress is a risk factor for multiple diseases of aging. Accelerated cellular aging as indexed by short telomere length has emerged as a potential common biological mechanism linking various forms of psychological stress and diseases of aging. Stress appraisals determine the degree and type of biological stress responses and altered stress appraisals may be a common psychological mechanism linking psychological stress and diseases of aging. However, no previous studies have examined the relationship between stress appraisals and telomere length. We exposed chronically stressed female caregivers and non-caregiving controls (N=50; M age=62.14±6.10) to a standardized acute laboratory stressor and measured their anticipatory and retrospective threat and challenge appraisals of the stressor. We hypothesized that threat and challenge appraisals would be associated with shorter and longer telomere length respectively, and that chronic caregiving stress would influence telomere length through altered stress appraisals. Higher anticipatory threat appraisals were associated with shorter age-adjusted telomere length (β=-.32, p=.03), but challenge appraisals and retrospective threat appraisals showed no independent association with telomere length. Caregivers reported significantly higher anticipatory (β=-.36, p=.006) and retrospective (β=-.29, p=.03) threat appraisals than controls, but similar challenge appraisals. Although there was no significant main effect of caregiver status on telomere length, caregiving had a significant indirect effect on telomere length through anticipatory threat appraisals. Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.