ArticleMolecular plant pathology2012
BcAtf1, a global regulator, controls various differentiation processes and phytotoxin production in Botrytis cinerea.
Article in Molecular plant pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 107 citations in OpenAlex.
- Chromatin accessibility profile and the role of PeAtf1 transcription factor in the postharvest pathogenHorticulture research · 2025Article
- ChIP-Seq Analysis of AtfA Interactions inInternational journal of molecular sciences · 2024Article
- The bZIP transcription factor ATF1 regulates blue light and oxidative stress responses inmLife · 2023Article
- Rho2 involved in development, stress response and pathogenicity of Fusarium oxysporum.World journal of microbiology & biotechnology · 2023Article
- Genome-Wide Characterization of Light-Regulated Gene Expression inInternational journal of molecular sciences · 2023Article
- The Regulatory Hub of Siderophore Biosynthesis in the Phytopathogenic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Genome-Wide Gene Expression Analyses of the AtfA/AtfB-Mediated Menadione Stress Response inCells · 2023Article
- Article
- Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen.BMC biology · 2022Article
- bZIP transcription factors PcYap1 and PcRsmA link oxidative stress response to secondary metabolism and development in Penicillium chrysogenum.Microbial cell factories · 2022Article
- Functional analysis of the bZIP-type transcription factors AtfA and AtfB inFrontiers in microbiology · 2022Article
- Role of the blue light receptor geneFrontiers in microbiology · 2022Article
- The BcLAE1 is involved in the regulation of ABA biosynthesis inFrontiers in microbiology · 2022Article
- Genome-Wide Identification of bZIP Transcription Factor Genes and Functional Analyses of Two Members inJournal of fungi (Basel, Switzerland) · 2021Article
- The impact of bZIP Atf1ortholog global regulators in fungi.Applied microbiology and biotechnology · 2021Review
- AtfA-Independent Adaptation to the Toxic Heavy Metal Cadmium inMicroorganisms · 2021Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Surviving the odds: From perception to survival of fungal phytopathogens under host-generated oxidative burst.Plant communications · 2021Review
- A Major Effect Gene Controlling Development and Pathogenicity inFrontiers in plant science · 2021Article
- A comprehensive transcription factor and DNA-binding motif resource for the construction of gene regulatory networks inComputational and structural biotechnology journal · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atf1-homologous basic region leucine zipper (bZIP) transcription factors are known to act downstream of the stress-activated mitogen-activated protein kinase (SAPK) cascade in mammals, as well as in several fungi; they regulate the transcription of genes involved in the general stress response. Functional analyses of BcAtf1 in Botrytis cinerea show that it is also connected to the SAPK BcSak1, as it shares several stress response target genes. However, Δbcatf1 mutants are not hypersensitive to osmotic or oxidative stress, as are Δbcsak1 mutants. Both BcSak1 and BcAtf1 are regulators of differentiation, but their roles in these processes are almost inverse as, in contrast with Δbcsak1, Δbcatf1 mutants are significantly impaired in conidia production and do not differentiate any sclerotia. They show extremely vigorous growth in axenic culture, with a thick layer of aerial hyphae and a marked increase in colonization efficiency on different host plants and tissues. In addition, the sensitivity to cell wall-interfering agents is increased strongly. Microarray analyses demonstrate that the loss of BcAtf1 leads to extensive transcriptional changes: apart from stress response genes, the expression of a broad set of genes, probably involved in primary metabolism, cell wall synthesis and development, is affected by BcAtf1. Unexpectedly, BcAtf1 also controls secondary metabolism: the mutant contains significantly elevated levels of phytotoxins. These data indicate that BcAtf1 controls a diversity of cellular processes and has broad regulatory functions.
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