Evidence map›Paper›PMID 22293025›Full record

ReviewTrends in cardiovascular medicine2010

Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb.

Saurabh Aggarwal, Christine Gross, Jeffrey R Fineman, Stephen M Black

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cardiovascular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01825369 (Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01825369 phase1withdrawnnot on this mapstarted 2014, after this paper: background citation

Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2020Enrolled0ConditionsHeart Septal Defects, Ventricular, Atrioventricular Septal DefectArmsIV L-carnitine
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Inflammation and DKK1-induced AKT activation contribute to endothelial dysfunction following NR2F2 loss.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Saurabh AggarwalPulmonary Disease Program, Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA.
Christine Gross
Jeffrey R Fineman
Stephen M Black
Augusta University Health · USUniversity of California, San Francisco · US

Funding

PERINATAL PULMONARY HYPERTENSION: DEVELOPMENT MEDIATORSR01HL061284 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FINEMAN, JEFFREY R · 1999 to 2016
$8.3M
PERINATAL REGULATION OF THE ENDOTHELIAL NOS GENER01HL060190 · NHLBI · UNIVERSITY OF MONTANA · PI Stephen M Black · 1998 to 2026
$7.1M
Research Training in Pediatric Critical Care MedicineT32HD049303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEFFREY R FINEMAN · 2006 to 2026
$3.1M
ROS in Pulmonary Hypertension: Role of ADMAR01HL067841 · NHLBI · UNIVERSITY OF MONTANA · PI BLACK, STEPHEN M · 2002 to 2011
$2.6M
Perinatal regulation of TGF-beta1 during vascular remodelingR01HL084739 · NHLBI · AUGUSTA UNIVERSITY · PI BLACK, STEPHEN M · 2007 to 2010
$1.5M
PRE-DOCTORAL TRAINING IN CARDIOVASCULAR BIOLOGYT32HL076146 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI POLLOCK, DAVID M · 2004 to 2013
$1.2M
Role of altered carnitine metabolism in perinatal endothelial dysfunctionR21HD057406 · NICHD · AUGUSTA UNIVERSITY · PI BLACK, STEPHEN M · 2008 to 2009
$423k
NHLBI NIH HHS 5T32HL076146NHLBI NIH HHS HL084739NHLBI NIH HHS HL60190NHLBI NIH HHS HL61284NHLBI NIH HHS HL67841NHLBI NIH HHS R01 HL060190NHLBI NIH HHS R01 HL061284NHLBI NIH HHS R01 HL067841NHLBI NIH HHS R01 HL084739NHLBI NIH HHS T32 HL076146NICHD NIH HHS R21 HD057406NICHD NIH HHS R21HD057406NICHD NIH HHS T32 HD049303
6 · The paper itself

Abstract

Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.

Indexed as

AnimalsDisease Models, AnimalEndothelium, VascularHeart Defects, CongenitalHumansHypertension, PulmonaryIntercellular Signaling Peptides and ProteinsMuscle, Smooth, VascularNitric Oxide SynthaseOxidative StressPulmonary CirculationSheepSignal TransductionIntercellular Signaling Peptides and ProteinsNitric Oxide Synthase

Identifiers

PMID22293025
PMCPMC3527074
OpenAlexW2168000017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.