Evidence map›Paper›PMID 22293008›Full record

ArticleDevelopment and psychopathology2012

Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children.

Daniel W Belsky, Avshalom Caspi, Louise Arseneault, Wiebke Bleidorn, Peter Fonagy, Marianne Goodman, Renate Houts, Terrie E Moffitt

Open access · greenAbstract readTwin Study
In one paragraph

Article in Development and psychopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Daniel W BelskyUniversity of North Carolina at Chapel Hill, USA. dbelsky@unc.edu
Avshalom Caspi
Louise Arseneault
Wiebke Bleidorn
Peter Fonagy
Marianne Goodman
Renate Houts
Terrie E Moffitt
Duke University · USKing's College London · GBBielefeld University · DEJames J. Peters VA Medical Center · USUniversity College London · GB

Funding

TRANSLATION AND DISSEMINATION COREP30DA023026 · NIDA · DUKE UNIVERSITY · PI HOYLE, RICK · 2008 to 2023
$19.6M
Human Development: Interdisiplinary Research TrainingT32HD007376 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL, PROPPER, CATHI BARBRA · 1988 to 2020
$8.0M
Uncovering and confirming gene-environment interactions in psychopathologyR01MH077874 · NIMH · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2007 to 2010
$1.6M
Social Inequality and Children's Mental HealthR01HD061298 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2009 to 2012
$478k
Medical Research Council G1002190Medical Research Council G9806489NICHD NIH HHS HD061298NICHD NIH HHS R01 HD061298NICHD NIH HHS T32 HD007376NIDA NIH HHS P30 DA023026NIMH NIH HHS MH077874NIMH NIH HHS R01 MH077874
6 · The paper itself

Abstract

It has been reported that borderline personality related characteristics can be observed in children, and that these characteristics are associated with increased risk for the development of borderline personality disorder. It is not clear whether borderline personality related characteristics in children share etiological features with adult borderline personality disorder. We investigated the etiology of borderline personality related characteristics in a longitudinal cohort study of 1,116 pairs of same-sex twins followed from birth through age 12 years. Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis. Exposure to harsh treatment in the family environment through age 10 years predicted borderline personality related characteristics at age 12 years. This association showed evidence of environmental mediation and was stronger among children with a family history of psychiatric illness, consistent with diathesis-stress models of borderline etiology. Results indicate that borderline personality related characteristics in children share etiological features with borderline personality disorder in adults and suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology.

Indexed as

AnxietyBorderline Personality DisorderChildDepressionDiseases in TwinsFamilyFemaleHumansLongitudinal StudiesMalePersonalityPersonality InventoryPsychotic DisordersSocial Environment

Identifiers

PMID22293008
PMCPMC3547630
OpenAlexW2089974511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.