ArticleSmall GTPases2011
PX-FERM proteins: A link between endosomal trafficking and signaling?
Article in Small GTPases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- VARP binds SNX27 to promote endosomal supercomplex formation on membranes.Science advances · 2025Article
- HPV-18 E6 enhances the interaction between EMILIN2 and SNX27 to promote WNT signaling.Journal of virology · 2024Article
- VARP binds SNX27 to promote endosomal supercomplex formation on membranes.bioRxiv : the preprint server for biology · 2024Article
- An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis.JCI insight · 2023Article
- SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus.Advances in biological regulation · 2022Article
- Article
- Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease.Frontiers in cell and developmental biology · 2021Review
- Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.The Journal of biological chemistry · 2020Article
- Non-BRAF Mutant Melanoma: Molecular Features and Therapeutical Implications.Frontiers in molecular biosciences · 2020Review
- Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways.PLoS pathogens · 2016Article
- Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.Journal of cell science · 2015Article
- Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1).The Journal of biological chemistry · 2014Article
- A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse.Bioarchitecture · 2014Article
- Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endosomes are the primary organelle where decisions are made as to whether endocytosed proteins will be sorted into degradative trafficking pathways or recycled back to the plasma membrane. This balance between cellular uptake and recycling regulates the plasma membrane composition and is therefore critical for many cellular processes such as nutrient uptake, neuronal transmission and cell migration.1 In addition to its well-known role in membrane trafficking, the endosome is increasingly being recognized as a critical cellular domain for regulated cell signaling. We recently showed that several proteins that regulate endosomal recycling, SNX17, SNX27 and SNX31 are structurally and functionally related.2 These proteins use an unusual FERM domain to bind specific endosomal cargo molecules, and most interestingly, we also found that these proteins use the same FERM domain to associate with the activated Ras small GTPase. Here we speculate on the potential dual role of the PX-FERM proteins in endosomal transport and as scaffolds that may be involved in endosomal Ras signaling processes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.