ArticleNeural plasticity2012
Modulation of CREB in the dorsal lateral geniculate nucleus of dark-reared mice.
Article in Neural plasticity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Structural and Functional Plasticity in the Dorsolateral Geniculate Nucleus of Mice following Bilateral Enucleation.Neuroscience · 2022Article
- Neuronal and Synaptic Plasticity in the Visual Thalamus in Mouse Models of Glaucoma.Frontiers in cellular neuroscience · 2020Article
- Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth. While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.
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Registered trials
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