ArticlePloS one2012
Mitochondrial-nuclear DNA interactions contribute to the regulation of nuclear transcript levels as part of the inter-organelle communication system.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative mitogenomic analysis ofFrontiers in physiology · 2024Article
- The toxicity of neodymium and genome-scale genetic screen of neodymium-sensitive gene deletion mutations in the yeast Saccharomyces cerevisiae.Environmental science and pollution research international · 2022Article
- Mitochondrial-nuclear epistasis underlying phenotypic variation in breast cancer pathology.Scientific reports · 2022Article
- Neonatal Rotenone Administration Induces Psychiatric Disorder-Like Behavior and Changes in Mitochondrial Biogenesis and Synaptic Proteins in Adulthood.Molecular neurobiology · 2021Article
- Spatial features for Escherichia coli genome organization.BMC genomics · 2015Article
- Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.Neuroscience letters · 2015Article
- Insights from space: potential role of diet in the spatial organization of chromosomes.Nutrients · 2014Review
- Potential roles for interactions between the mitochondrial and nuclear DNA throughout the cell cycle of Schizosaccharomyces pombe.Mitochondrion · 2014Article
- The missing story behind Genome Wide Association Studies: single nucleotide polymorphisms in gene deserts have a story to tell.Frontiers in genetics · 2014Review
- Genome conformation capture reveals that the Escherichia coli chromosome is organized by replication and transcription.Nucleic acids research · 2013Article
- The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?Biomolecular concepts · 2013Review
- Article
- Prediction of gene phenotypes based on GO and KEGG pathway enrichment scores.BioMed research international · 2013Article
- The role of mitochondria from mature oocyte to viable blastocyst.Obstetrics and gynecology international · 2013Article
- The statistical-mechanics of chromosome conformation capture.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear and mitochondrial organelles must maintain a communication system. Loci on the mitochondrial genome were recently reported to interact with nuclear loci. To determine whether this is part of a DNA based communication system we used genome conformation capture to map the global network of DNA-DNA interactions between the mitochondrial and nuclear genomes (Mito-nDNA) in Saccharomyces cerevisiae cells grown under three different metabolic conditions. The interactions that form between mitochondrial and nuclear loci are dependent on the metabolic state of the yeast. Moreover, the frequency of specific mitochondrial-nuclear interactions (i.e. COX1-MSY1 and Q0182-RSM7) showed significant reductions in the absence of mitochondrial encoded reverse transcriptase machinery. Furthermore, these reductions correlated with increases in the transcript levels of the nuclear loci (MSY1 and RSM7). We propose that these interactions represent an inter-organelle DNA mediated communication system and that reverse transcription of mitochondrial RNA plays a role in this process.
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