Evidence map›Paper›PMID 22292043›Full record

ArticlePloS one2012

Brd1 gene in maize encodes a brassinosteroid C-6 oxidase.

Irina Makarevitch, Addie Thompson, Gary J Muehlbauer, Nathan M Springer

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. First brassinosteroid-based dwarf mutant discovered and characterized in grapevine.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Article
  5. Article
  6. Article
  7. Frontiers in plant science · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. STay tunEd: mutational analysis of theFrontiers in plant science · 2025
    Article
  16. Review
  17. Phenotypic characterization and genetic mapping of the semi-dwarf mutant sdw9 in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024
    Article
  18. Review
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Irina MakarevitchDepartment of Biology, Hamline University, Saint Paul, Minnesota, United States of America. imakarevitch01@hamline.edu
Addie Thompson
Gary J Muehlbauer
Nathan M Springer
University of Minnesota · USHamline University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of brassinosteroids in plant growth and development has been well-characterized in a number of plant species. However, very little is known about the role of brassinosteroids in maize. Map-based cloning of a severe dwarf mutant in maize revealed a nonsense mutation in an ortholog of a brassinosteroid C-6 oxidase, termed brd1, the gene encoding the enzyme that catalyzes the final steps of brassinosteroid synthesis. Homozygous brd1-m1 maize plants have essentially no internode elongation and exhibit no etiolation response when germinated in the dark. These phenotypes could be rescued by exogenous application of brassinolide, confirming the molecular defect in the maize brd1-m1 mutant. The brd1-m1 mutant plants also display alterations in leaf and floral morphology. The meristem is not altered in size but there is evidence for differences in the cellular structure of several tissues. The isolation of a maize mutant defective in brassinosteroid synthesis will provide opportunities for the analysis of the role of brassinosteroids in this important crop system.

Indexed as

Amino Acid SequenceBrassinosteroidsChromosome MappingChromosomes, PlantCloning, MolecularCytochrome P-450 Enzyme SystemGenes, PlantMolecular Sequence DataMutant ProteinsPhenotypePhylogenyPlant DiseasesPlants, Genetically ModifiedSequence Homology, Amino AcidZea maysBrassinosteroidsCytochrome P-450 Enzyme SystemMutant Proteins

Identifiers

PMID22292043
PMCPMC3266906
OpenAlexW2042143257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.