ArticlePloS one2012
Interactive responses of a thalamic neuron to formalin induced lasting pain in behaving mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- The Effect of Optogenetic Inhibition of the Anterior Cingulate Cortex in Neuropathic Pain Following Sciatic Nerve Injury.Journal of molecular neuroscience : MN · 2021Article
- Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex.Scientific reports · 2021Article
- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties.Experimental neurobiology · 2019Article
- Ablation of IB4 non-peptidergic afferents in the rat facet joint prevents injury-induced pain and thalamic hyperexcitability via supraspinal glutamate transporters.Neuroscience letters · 2017Article
- Auditory thalamic circuits and GABAHearing research · 2017Review
- Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.Scientific reports · 2017Article
- Differential Responses of Thalamic Reticular Neurons to Nociception in Freely Behaving Mice.Frontiers in behavioral neuroscience · 2016Article
- Thalamic Bursts and the Epic Pain Model.Frontiers in computational neuroscience · 2016Article
- Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain.F1000Research · 2016Article
- Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.British journal of pharmacology · 2015Article
- Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice.PloS one · 2015Article
- Discrete pattern of burst stimulation in the ventrobasal thalamus for anti-nociception.PloS one · 2013Article
- Urethane anesthesia depresses activities of thalamocortical neurons and alters its response to nociception in terms of dual firing modes.Frontiers in behavioral neuroscience · 2013Article
- Brain stimulation patterns emulating endogenous thalamocortical input to parvalbumin-expressing interneurons reduce nociception in mice.Brain stimulationArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Thalamocortical (TC) neurons are known to relay incoming sensory information to the cortex via firing in tonic or burst mode. However, it is still unclear how respective firing modes of a single thalamic relay neuron contribute to pain perception under consciousness. Some studies report that bursting could increase pain in hyperalgesic conditions while others suggest the contrary. However, since previous studies were done under either neuropathic pain conditions or often under anesthesia, the mechanism of thalamic pain modulation under awake conditions is not well understood. We therefore characterized the thalamic firing patterns of behaving mice in response to nociceptive pain induced by inflammation. Our results demonstrated that nociceptive pain responses were positively correlated with tonic firing and negatively correlated with burst firing of individual TC neurons. Furthermore, burst properties such as intra-burst-interval (IntraBI) also turned out to be reliably correlated with the changes of nociceptive pain responses. In addition, brain stimulation experiments revealed that only bursts with specific bursting patterns could significantly abolish behavioral nociceptive responses. The results indicate that specific patterns of bursting activity in thalamocortical relay neurons play a critical role in controlling long-lasting inflammatory pain in awake and behaving mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.