ArticlePloS one2012
Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of ATF2/TSC1 on epilepsy by modulating the microphages polarization of microglia.Scientific reports · 2025Article
- Pungency Perception and the Interaction with Basic Taste Sensations: An Overview.Foods (Basel, Switzerland) · 2023Review
- Pharmacology of the Umami Taste Receptor.Handbook of experimental pharmacology · 2022Article
- Chemical and electrical synaptic interactions among taste bud cells.Current opinion in physiology · 2021Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Substance P as a putative efferent transmitter mediates GABAergic inhibition in mouse taste buds.British journal of pharmacology · 2018Article
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- The effect of imiquimod on taste bud calcium transients and transmitter secretion.British journal of pharmacology · 2016Article
- Glutamate: Tastant and Neuromodulator in Taste Buds.Advances in nutrition (Bethesda, Md.) · 2016Review
- Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa.Histochemistry and cell biology · 2016Article
- Calcitonin Gene-Related Peptide Reduces Taste-Evoked ATP Secretion from Mouse Taste Buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors.PloS one · 2015Article
- Synaptic communication and signal processing among sensory cells in taste buds.The Journal of physiology · 2014Article
- A taste for ATP: neurotransmission in taste buds.Frontiers in cellular neuroscience · 2013Review
- Thrombospondin 1 promotes synaptic formation in bone marrow-derived neuron-like cells.Neural regeneration research · 2013Article
- Egr-1 induction provides a genetic response to food aversion in zebrafish.Frontiers in behavioral neuroscience · 2013Article
- Taste buds as peripheral chemosensory processors.Seminars in cell & developmental biology · 2013Review
- Diet-induced obesity reduces the responsiveness of the peripheral taste receptor cells.PloS one · 2013Article
- Natural product of gambier (Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated efferent transmission. We also studied what effect glutamate exerts on taste bud function. We isolated mouse taste buds and taste cells, conducted functional imaging using Fura 2, and used cellular biosensors to monitor taste-evoked transmitter release. The findings show that a large fraction of Presynaptic (Type III) taste bud cells (∼50%) respond to 100 µM glutamate, NMDA, or kainic acid (KA) with an increase in intracellular Ca(2+). In contrast, Receptor (Type II) taste cells rarely (4%) responded to 100 µM glutamate. At this concentration and with these compounds, these agonists activate glutamatergic synaptic receptors, not glutamate taste (umami) receptors. Moreover, applying glutamate, NMDA, or KA caused taste buds to secrete 5-HT, a Presynaptic taste cell transmitter, but not ATP, a Receptor cell transmitter. Indeed, glutamate-evoked 5-HT release inhibited taste-evoked ATP secretion. The findings are consistent with a role for glutamate in taste buds as an inhibitory efferent transmitter that acts via ionotropic synaptic glutamate receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.