ArticlePloS one2012
Requirement of mouse BCCIP for neural development and progenitor proliferation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Medulloblastomas Initiated by Homologous Recombination Defects in Mice.The American journal of pathology · 2024Article
- Requirement of Bccip for the Regeneration of Intestinal Progenitors.The American journal of pathology · 2021Article
- BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis.Nucleic acids research · 2020Article
- Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice.The American journal of pathology · 2020Article
- Preferential Mapping of Sex-Biased Differentially-Expressed Genes of Larvae to the Sex-Determining Region of Flathead Grey Mullet (Frontiers in genetics · 2020Article
- Insights into the ubiquitin-proteasome system of human embryonic stem cells.Scientific reports · 2018Article
- Roles of BCCIP deficiency in mammary tumorigenesis.Breast cancer research : BCR · 2017Article
- Article
- High Expression of BCCIP β Can Promote Proliferation of Esophageal Squamous Cell Carcinoma.Digestive diseases and sciences · 2017Article
- Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP.American journal of translational research · 2017Article
- Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.Advances in experimental medicine and biology · 2017Review
- Extremely Low-Frequency Electromagnetic Fields Affect the miRNA-Mediated Regulation of Signaling Pathways in the GC-2 Cell Line.PloS one · 2015Article
- Article
- BCCIP suppresses tumor initiation but is required for tumor progression.Cancer research · 2013Article
- Bicaudal-C spatially controls translation of vertebrate maternal mRNAs.RNA (New York, N.Y.) · 2013Article
- Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight.Epigenetics · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution.
Funding
Abstract
Multiple DNA repair pathways are involved in the orderly development of neural systems at distinct stages. The homologous recombination (HR) pathway is required to resolve stalled replication forks and critical for the proliferation of progenitor cells during neural development. BCCIP is a BRCA2 and CDKN1A interacting protein implicated in HR and inhibition of DNA replication stress. In this study, we determined the role of BCCIP in neural development using a conditional BCCIP knock-down mouse model. BCCIP deficiency impaired embryonic and postnatal neural development, causing severe ataxia, cerebral and cerebellar defects, and microcephaly. These development defects are associated with spontaneous DNA damage and subsequent cell death in the proliferative cell populations of the neural system during embryogenesis. With in vitro neural spheroid cultures, BCCIP deficiency impaired neural progenitor's self-renewal capability, and spontaneously activated p53. These data suggest that BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.