ArticlePloS one2012
Characterization of NLRP12 during the development of allergic airway disease in mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The effect of camel milk on house dust mite allergen induced asthma model in BALB/C mice.PloS one · 2025Article
- Nasal virus infection induces asthma exacerbation through B-cell-dependent recruitment of inflammatory monocytes.International forum of allergy & rhinology · 2024Article
- The role of NLRP3 and NLRP12 inflammasomes in glioblastoma.Genes and immunity · 2024Review
- Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.iScience · 2023Article
- CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer.iScience · 2023Article
- Neuropilin-2 regulates airway inflammation in a neutrophilic asthma model.Immunity, inflammation and disease · 2022Article
- NLRX1 Deficiency Alters the Gut Microbiome and Is Further Exacerbated by Adherence to a Gluten-Free Diet.Frontiers in immunology · 2022Article
- Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness.JCI insight · 2021Article
- Immunological Roles of NLR in Allergic Diseases and Its Underlying Mechanisms.International journal of molecular sciences · 2021Review
- The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.Cell host & microbe · 2018Article
- Modulating inflammation through the negative regulation of NF-κB signaling.Journal of leukocyte biology · 2018Review
- Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma.BMC genomics · 2017Article
- TIPS pentacene loaded PEO-PDLLA core-shell nanoparticles have similar cellular uptake dynamics in M1 and M2 macrophages and in corresponding in vivo microenvironments.Nanomedicine : nanotechnology, biology, and medicine · 2017Article
- NLRP12 Inflammasome Expression in the Rat Brain in Response to LPS during Morphine Tolerance.Brain sciences · 2017Article
- Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure.The Journal of general virology · 2016Review
- Emerging significance of NLRs in inflammatory bowel disease.Inflammatory bowel diseases · 2014Review
- Inflammasome Activity in Non-Microbial Lung Inflammation.Journal of environmental immunology and toxicology · 2014Article
- Non-Inflammasome Forming NLRs in Inflammation and Tumorigenesis.Frontiers in immunology · 2014Review
- Licensing Adaptive Immunity by NOD-Like Receptors.Frontiers in immunology · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Among the 22 members of the nucleotide binding-domain, leucine rich repeat-containing (NLR) family, less than half have been functionally characterized. Of those that have been well studied, most form caspase-1 activating inflammasomes. NLRP12 is a unique NLR that has been shown to attenuate inflammatory pathways in biochemical assays and mediate the lymph node homing of activated skin dendritic cells in contact hypersensitivity responses. Since the mechanism between these two important observations remains elusive, we further evaluated the contribution of NLRP12 to organ specific adaptive immune responses by focusing on the lung, which, like skin, is exposed to both exogenous and endogenous inflammatory agents. In models of allergic airway inflammation induced by either acute ovalbumin (OVA) exposure or chronic house dust mite (HDM) antigen exposure, Nlrp12(-/-) mice displayed subtle differences in eosinophil and monocyte infiltration into the airways. However, the overall development of allergic airway disease and airway function was not significantly altered by NLRP12 deficiency. Together, the combined data suggest that NLRP12 does not play a vital role in regulating Th2 driven airway inflammation using common model systems that are physiologically relevant to human disease. Thus, the allergic airway inflammation models described here should be appropriate for subsequent studies that seek to decipher the contribution of NLRP12 in mediating the host response to agents associated with asthma exacerbation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.