ArticlePloS one2012
Characterization and comparison of the leukocyte transcriptomes of three cattle breeds.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming.PloS one · 2013Trial
- Differential gene expression in peripheral leukocytes of pre-weaned Holstein heifer calves with respiratory disease.PloS one · 2023Article
- Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Frontiers in genetics · 2021Article
- Common and Differential Dynamics of the Function of Peripheral Blood Mononuclear Cells between Holstein and Jersey Cows in Heat-Stress Environment.Animals : an open access journal from MDPI · 2020Article
- Identification of candidate genes for milk production traits by RNA sequencing on bovine liver at different lactation stages.BMC genetics · 2020Article
- Systematic identification of long intergenic non-coding RNAs expressed in bovine oocytes.Reproductive biology and endocrinology : RB&E · 2020Article
- Comparative Analysis of the Liver Transcriptome among Cattle Breeds Using RNA-seq.Veterinary sciences · 2019Article
- Article
- Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition.BMC genomics · 2018Article
- Article
- Transcriptome analysis of the pectoral muscles of local chickens and commercial broilers using Ribo-Zero ribonucleic acid sequencing.PloS one · 2017Article
- Evaluation of SCD and FASN Gene Expression in Baluchi, Iran-Black, and Arman Sheep.Reports of biochemistry & molecular biology · 2016Article
- Single Nucleotide Polymorphism Discovery in Bovine Pituitary Gland Using RNA-Seq Technology.PloS one · 2016Article
- Characterisation of the Whole Blood mRNA Transcriptome in Holstein-Friesian and Jersey Calves in Response to Gradual Weaning.PloS one · 2016Article
- Identification of large intergenic non-coding RNAs in bovine muscle using next-generation transcriptomic sequencing.BMC genomics · 2014Article
- Comparison of transcriptional profiles of Clostridium thermocellum grown on cellobiose and pretreated yellow poplar using RNA-Seq.Frontiers in microbiology · 2014Article
- Identification of novel transcripts and noncoding RNAs in bovine skin by deep next generation sequencing.BMC genomics · 2013Article
- Gene-based single nucleotide polymorphism discovery in bovine muscle using next-generation transcriptomic sequencing.BMC genomics · 2013Article
- Application of Top-Down and Bottom-up Systems Approaches in Ruminant Physiology and Metabolism.Current genomics · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, mRNA-Seq was used to characterize and compare the leukocyte transcriptomes from two taurine breeds (Holstein and Jersey), and one indicine breed (Cholistani). At the genomic level, we identified breed-specific base changes in protein coding regions. Among 7,793,425 coding bases, only 165 differed between Holstein and Jersey, and 3,383 (0.04%) differed between Holstein and Cholistani, 817 (25%) of which resulted in amino acid changes in 627 genes. At the transcriptional level, we assembled transcripts and estimated their abundances including those from more than 3,000 unannotated intergeneic regions. Differential gene expression analysis showed a high similarity between Holstein and Jersey, and a much greater difference between the taurine breeds and the indicine breed. We identified gene ontology pathways that were systematically altered, including the electron transport chain and immune response pathways that may contribute to different levels of heat tolerance and disease resistance in taurine and indicine breeds. At the post-transcriptional level, sequencing mRNA allowed us to identify a number of genes undergoing differential alternative splicing among different breeds. This study provided a high-resolution survey of the variation between bovine transcriptomes at different levels and may provide important biological insights into the phenotypic differentiation among cattle breeds.
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