ArticlePloS one2012
Wolbachia-mediated male killing is associated with defective chromatin remodeling.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
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- Elucidating the Molecular Mechanisms of Sex Ratio Distortion Mediated by Cytoplasmic Symbionts.Genome biology and evolution · 2025Review
- Microbial Community Structure and Metabolic Function in the Venom Glands of the Predatory Stink Bug,Insects · 2024Article
- A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Maintenance and Evaluation of Wolbachia Male-Killers of Dipterans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A comprehensive review ofFrontiers in immunology · 2024Review
- Combined actions of bacteriophage-encoded genes iniScience · 2023Article
- Sex determination systems as the interface between male-killing bacteria and their hosts.Proceedings. Biological sciences · 2022Review
- Delete and survive: strategies of programmed genetic material elimination in eukaryotes.Biological reviews of the Cambridge Philosophical Society · 2022Review
- The Tsetse Metabolic Gambit: Living on Blood by Relying on Symbionts Demands Synchronization.Frontiers in microbiology · 2022Review
- A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO geneeLife · 2021Article
- Mechanistically comparing reproductive manipulations caused by selfish chromosomes and bacterial symbionts.Heredity · 2021Review
- Intracellular Interactions Between Arboviruses andFrontiers in cellular and infection microbiology · 2021Review
- Synergism between Hydramethylnon andInsects · 2020Article
- Article
- Trends in Symbiont-Induced Host Cellular Differentiation.Results and problems in cell differentiation · 2020Article
- The phage gene wmk is a candidate for male killing by a bacterial endosymbiont.PLoS pathogens · 2019Article
- TheMicrobiology spectrum · 2019Review
- Common and unique strategies of male killing evolved in two distinctProceedings. Biological sciences · 2018Article
- Uncovering the hidden players in Lepidoptera biology: the heritable microbial endosymbionts.PeerJ · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male killing, induced by different bacterial taxa of maternally inherited microorganisms, resulting in highly distorted female-biased sex-ratios, is a common phenomenon among arthropods. Some strains of the endosymbiont bacteria Wolbachia have been shown to induce this phenotype in particular insect hosts. High altitude populations of Drosophila bifasciata infected with Wolbachia show selective male killing during embryonic development. However, since this was first reported, circa 60 years ago, the interaction between Wolbachia and its host has remained unclear. Herein we show that D. bifasciata male embryos display defective chromatin remodeling, improper chromatid segregation and chromosome bridging, as well as abnormal mitotic spindles and gradual loss of their centrosomes. These defects occur at different times in the early development of male embryos leading to death during early nuclear division cycles or large defective areas of the cellular blastoderm, culminating in abnormal embryos that die before eclosion. We propose that Wolbachia affects the development of male embryos by specifically targeting male chromatin remodeling and thus disturbing mitotic spindle assembly and chromosome behavior. These are the first observations that demonstrate fundamental aspects of the cytological mechanism of male killing and represent a solid base for further molecular studies of this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.