ArticleEvidence-based complementary and alternative medicine : eCAM2012
Pharmacological Basis for the Medicinal Use of Lepidium sativum in Airways Disorders.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Phytochemical insights and pharmacological advances of Lepidium sativum L. (garden cress): bridging traditional medicine and evidence-based therapeutics.Journal, genetic engineering & biotechnology · 2026Review
- Composition, medicinal values, and threats of plants used in indigenous medicine in Jawi District, Ethiopia: implications for conservation and sustainable use.Scientific reports · 2024Article
- Garden cress seeds: a review on nutritional composition, therapeutic potential, and industrial utilization.Food science & nutrition · 2024Review
- In-vivo Immunomodulatory Activities of Essential Oils ofImmunoTargets and therapy · 2024Article
- In vitro anti-plasmodial activity of three selected medicinal plants that are used in local traditional medicine in Amhara region of Ethiopia.BMC pharmacology & toxicology · 2023Article
- Evidence for Health-Promoting Properties ofTurkish journal of pharmaceutical sciences · 2022Article
- In Silico and Ex Vivo Studies on the Spasmolytic Activities of Fenchone Using Isolated Guinea Pig Trachea.Molecules (Basel, Switzerland) · 2022Article
- Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats.BioMed research international · 2022Article
- Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.Pharmaceutical biology · 2021Article
- Complementary effects of coenzyme Q10 andInternational journal of reproductive biomedicine · 2021Article
- Indian Medicinal Plants and Formulations and Their Potential Against COVID-19-Preclinical and Clinical Research.Frontiers in pharmacology · 2020Review
- Use of Natural Products in Asthma Treatment.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Effect of Ultraviolet-C Radiation and Melatonin Stress on Biosynthesis of Antioxidant and Antidiabetic Metabolites Produced in In Vitro Callus Cultures ofInternational journal of molecular sciences · 2019Article
- Inhibitory effects of3 Biotech · 2018Article
- A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders.Pharmaceutical biology · 2017Article
- Antispasmodic, bronchodilator, vasorelaxant and cardiosuppressant effects of Buxus papillosa.BMC complementary and alternative medicine · 2017Article
- Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum.BMC complementary and alternative medicine · 2013Article
- Promising effect of Magliasa, a traditional Iranian formula, on experimental colitis on the basis of biochemical and cellular findings.World journal of gastroenterology · 2013Article
- Effects of Nigella sativa and Lepidium sativum on cyclosporine pharmacokinetics.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lepidium sativum is widely used in folk medicine for treatment of hyperactive airways disorders, such as asthma, bronchitis and cough. The crude extract of Lepidium sativum (Ls.Cr) inhibited carbachol (CCh, 1 μM-) and K(+) (80 mM-) induced contractions in a pattern similar to that of dicyclomine. Ls.Cr at 0.03 mg/mL produced a rightward parallel shift of CCh curves, followed by nonparallel shift at higher concentration (0.1 mg/mL), suppressing maximum response, similar to that caused by dicyclomine. Pretreatment of tissues with Ls.Cr (0.1-0.3 mg/mL) shifted Ca(++) concentration-response curves (CRCs) to right, as produced by verapamil. Ls.Cr at low concentrations (0.03-0.1 mg/mL) caused leftward shift of isoprenaline-induced inhibitory CRCs, like that caused by rolipram, a phosphodiesterase (PDE) inhibitor. These results indicate that bronchodilatory effect of Lepidium sativum is mediated through a combination of anticholinergic, Ca(++) antagonist and PDE inhibitory pathways, which provides sound mechanistic background for its medicinal use in the overactive airways disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.