ArticleArchives of medical science : AMS2011
Cigarette smoking induces overexpression of c-Met receptor in microvessels of oral lichen planus.
Article in Archives of medical science : AMS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- The Impact ofJournal of Cancer · 2025Article
- The age-related incidence of male genital lichen sclerosus is triphasic.Skin health and disease · 2024Article
- Review
- What can we learn from treatments of oral lichen planus?Frontiers in cellular and infection microbiology · 2024Review
- The effect of smoking on clinical presentation and expression of TLR-2 and CD34 in Oral lichen Planus patients: clinical and immunohistochemical study.BMC oral health · 2020Article
- Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs.Molecular oncology · 2018Article
- Successful Treatment of Hepatitis C Virus-associated Oral Lichen Planus by Interferon-free Therapy with Direct-acting Antivirals.Clinical and translational gastroenterology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCigarette smoking is related to many pathological conditions; however, chemical substances affect the oral cavity first, so it is important to consider its influence on oral mucosa and oral potentially pre-malignant lesions. The aim of this study was to investigate the effect of smoking on microvessel density in oral lichen planus. Special emphasis was placed on examining the relationship between the expression of c-Met receptor in blood vessels and smoking habits. MATERIAL AND
methodsThis study included 34 patients with oral lichen planus diagnosed clinically and verified by histopathological examination and 12 healthy individuals as controls. Biopsy of oral mucosa was performed and specimens were examined for immunohistochemical CD34 and c-Met receptor expression. The microvessel density was established by evaluation of the five most vascular areas within a section.
resultsCompared to normal oral mucosa, in lichen planus patients, significantly higher blood vessel density and c-Met expression were noted. Irregular distribution of microvessels was typical for oral lichen planus. Also, microvessel density was higher in cigarette smoking patients' tissues than in non-smoker specimens. Furthermore, the association of c-Met expression with smoking habit was statistically significant.
conclusionsCigarette smoking habit has a direct impact on the oral lichen planus course; therefore, close follow-up of these patients is mandatory.
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