ArticleArchives of medical science : AMS2011
Effects of ibandronate-hydroxyapatite on resorptive activity of osteoclasts.
Article in Archives of medical science : AMS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Dietary calcium and phosphorus levels in lactating Shenxian sows regulate growth performance and bone metabolism in suckling piglets.Frontiers in veterinary science · 2026Article
- Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions.Scientific reports · 2018Article
- Effect of a local, one time, low-dose injection of zoledronic acid on titanium implant osseointegration in ovariectomized rats.Archives of medical science : AMS · 2016Article
- Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study.Archives of medical science : AMS · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBisphosphonates (BPs) can be locally used to improve the osteogenesis around hydroxyapatite (HA) implants. However, there are almost no reports discussing the effects of BPs in the bound state with HA on osteoclasts. Ibandronate is a BP widely used in clinical practice. This study was designed to evaluate the effects of ibandronate combined with HA on the morphology and resorptive activity of osteoclasts. MATERIAL AND
methodsThe HA and ibandronate-HA were prepared. Osteoclasts were isolated from Sprague-Dawley rats and then the cells were cultured with both HA and ibandronate-HA. Then the cell morphology was inspected by inverted phase contrast microscope and transmission electron microscopy observation. The resorptive activity was tested using the dyeing agent seminaphthofluorescein and bone resorption assay.
resultsCompared with the control group, the osteoclasts demonstrated morphological alterations, and the hydrogen ion concentration was significantly lower in the ibandronate-HA group. Areas of the resorption pits formed by the osteoclasts were significantly smaller, the trabecula thickness appeared thicker, and concentration of CTx was also significantly lower in the experimental group.
conclusionsResorptive activity of osteoclasts cultured with ibandronate-HA was weaker than that of the control group. Ibandronate on HA in the bound state could maintain its action as an inhibitor to osteoclasts.
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