ArticleFrontiers in neuroscience2012
Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identification of the FSH-RH as the other gonadotropin-releasing hormone.Nature communications · 2024Article
- Article
- Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases.Biomedicines · 2022Review
- Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors.Biomolecules & therapeutics · 2017Review
- Looking for the bird Kiss: evolutionary scenario in sauropsids.BMC evolutionary biology · 2014Article
- Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?Frontiers in endocrinology · 2014Review
- The neuropeptide complement of the marine annelid Platynereis dumerilii.BMC genomics · 2013Article
- Insight from the lamprey genome: glimpsing early vertebrate development via neuroendocrine-associated genes and shared synteny of gonadotropin-releasing hormone (GnRH).General and comparative endocrinology · 2013Article
- In silico analysis of the regulatory region of the Yellowtail Kingfish and Zebrafish Kiss and Kiss receptor genes.Fish physiology and biochemistry · 2013Article
- A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates.PloS one · 2013Article
- Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons.PloS one · 2013Article
- Regulation of gonadotropins by corticotropin-releasing factor and urocortin.Frontiers in endocrinology · 2013Article
- Comparative evolutionary histories of kisspeptins and kisspeptin receptors in vertebrates reveal both parallel and divergent features.Frontiers in endocrinology · 2012Article
- Multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family.PloS one · 2012Article
- Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.Frontiers in endocrinology · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuropeptides gonadotropin-releasing hormone (GnRH) and kisspeptin (KiSS), and their receptors gonadotropin-releasing hormone receptor (GnRHR) and kisspeptin receptor (KiSSR) play key roles in vertebrate reproduction. Multiple paralogous isoforms of these genes have been identified in various vertebrate species. Two rounds of genome duplication in early vertebrates likely contributed to the generation of these paralogous genes. Genome synteny and phylogenetic analyses in a variety of vertebrate species have provided insights into the evolutionary origin of and relationship between paralogous genes. The paralogous forms of these neuropeptides and their receptors have coevolved to retain high selectivity of the ligand-receptor interaction. These paralogous forms have become subfunctionalized, neofunctionalized, or dysfunctionalized during evolution. This article reviews the evolutionary mechanism of GnRH/GnRHR and KiSS/KiSSR, and the fate of the duplicated paralogs in vertebrates.
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