ArticlePLoS genetics2012
Two-component elements mediate interactions between cytokinin and salicylic acid in plant immunity.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
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Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it, 275 citations in OpenAlex.
- Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis.Plant physiology · 2013Pooled it
- Hopeaphenol targets histidine kinase signaling across kingdoms to suppress bacterial virulence and potentiate plant immunity.bioRxiv : the preprint server for biology · 2026Article
- Comparative Transcriptomic Analysis of Two Apple Cultivars in Response to Dual Cytokinin Applied In Vitro.Plants (Basel, Switzerland) · 2026Article
- Elucidating the differential antiviral action of a plant growth promoting rhizobacterium against three genetically distant virus species.Frontiers in plant science · 2026Article
- Chemically Induced Resistance to Pathogen Infection in Arabidopsis by Cytokinin (Trans-Zeatin) and an Aromatic Cytokinin Arabinoside.Molecular plant pathology · 2026Article
- Integrated multi-omics analysis reveals hormonal and nutrient networks regulating sugarcane tillering.Frontiers in plant science · 2026Article
- Cytokinin derivatives as tools to enhance plant stress resilience.Frontiers in plant science · 2026Review
- BvHP4b gene in red beet promotes tuber enlargement and enhances resistance to Pst DC3000.BMC genomics · 2025Article
- Temporal Shifts in Hormone Signaling Networks Orchestrate Soybean Floral Development Under Field Conditions: An RNA-Seq Study.International journal of molecular sciences · 2025Article
- Transcriptional and phytohormonal responses to simulated animal grazing in Leymus chinensis.Plant cell reports · 2025Article
- Article
- Enhancing sweet potato production: a comprehensive analysis of the role of auxins and cytokinins in micropropagation.Planta · 2025Review
- Salicylic acid: The roles in plant immunity and crosstalk with other hormones.Journal of integrative plant biology · 2025Review
- Exogenous bacterial cellulose induces plant tissue regeneration through the regulation of cytokinin and defense networks.Science advances · 2025Article
- A pathogen effector HaRxL10 hijacks the circadian clock component CHE to perturb both plant development and immunity.Nature communications · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Genome editing approaches to harness cytokinin-salicylic acid crosstalk for plant protection.Frontiers in genome editing · 2025Article
- Drought-induced molecular changes in crown of various barley phytohormone mutants.Plant signaling & behavior · 2024Article
- Recent Advances in Gene Mining and Hormonal Mechanism for Brown Planthopper Resistance in Rice.International journal of molecular sciences · 2024Review
- Cytokinin Plays a Multifaceted Role in Ralstonia solanacearum-Triggered Plant Disease Development.Molecular plant pathology · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Recent studies have revealed an important role for hormones in plant immunity. We are now beginning to understand the contribution of crosstalk among different hormone signaling networks to the outcome of plant-pathogen interactions. Cytokinins are plant hormones that regulate development and responses to the environment. Cytokinin signaling involves a phosphorelay circuitry similar to two-component systems used by bacteria and fungi to perceive and react to various environmental stimuli. In this study, we asked whether cytokinin and components of cytokinin signaling contribute to plant immunity. We demonstrate that cytokinin levels in Arabidopsis are important in determining the amplitude of immune responses, ultimately influencing the outcome of plant-pathogen interactions. We show that high concentrations of cytokinin lead to increased defense responses to a virulent oomycete pathogen, through a process that is dependent on salicylic acid (SA) accumulation and activation of defense gene expression. Surprisingly, treatment with lower concentrations of cytokinin results in increased susceptibility. These functions for cytokinin in plant immunity require a host phosphorelay system and are mediated in part by type-A response regulators, which act as negative regulators of basal and pathogen-induced SA-dependent gene expression. Our results support a model in which cytokinin up-regulates plant immunity via an elevation of SA-dependent defense responses and in which SA in turn feedback-inhibits cytokinin signaling. The crosstalk between cytokinin and SA signaling networks may help plants fine-tune defense responses against pathogens.
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