ReviewPLoS genetics2012
Tempo and mode in evolution of transcriptional regulation.
Review in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed.
- Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses.Nature communications · 2026Article
- RNA-sequencing Analysis of Hybrid Females Reveals a Dominance of Expression of Alleles From Outcrossing Species Over Those From Selfing Species.Genome biology and evolution · 2025Article
- Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.Molecular biology and evolution · 2025Article
- Single-cell transcriptomics reveals evolutionary reconfiguration of embryonic cell fate specification in the sea urchinbioRxiv : the preprint server for biology · 2024Article
- Human gene regulatory evolution is driven by the divergence of regulatory element function in both cis and trans.Cell genomics · 2024Article
- Transcriptional misexpression in hybrids between species linked by gene flow is associated with patterns of sequence divergence.Genome biology and evolution · 2023Article
- Long-read genome assemblies reveal aZoological research · 2023Article
- Modular Evolution of the Drosophila Metabolome.Molecular biology and evolution · 2022Article
- Widespread misregulation of inter-species hybrid transcriptomes due to sex-specific and sex-chromosome regulatory evolution.PLoS genetics · 2021Article
- Cis and trans effects differentially contribute to the evolution of promoters and enhancers.Genome biology · 2020Article
- Effects of parental genetic divergence on gene expression patterns in interspecific hybrids of Camellia.BMC genomics · 2019Article
- CompensatoryEvolution letters · 2019Article
- Quantitative Comparison of the Anterior-Posterior Patterning System in the Embryos of FiveG3 (Bethesda, Md.) · 2019Article
- Testes Proteases Expression and Hybrid Male Sterility Between Subspecies ofG3 (Bethesda, Md.) · 2019Article
- Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age.Molecular biology and evolution · 2019Article
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
- Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species.Genome biology and evolution · 2017Article
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- Cis-regulatory programs in the development and evolution of vertebrate paired appendages.Seminars in cell & developmental biology · 2016Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Perennial questions of evolutionary biology can be applied to gene regulatory systems using the abundance of experimental data addressing gene regulation in a comparative context. What is the tempo (frequency, rate) and mode (way, mechanism) of transcriptional regulatory evolution? Here we synthesize the results of 230 experiments performed on insects and nematodes in which regulatory DNA from one species was used to drive gene expression in another species. General principles of regulatory evolution emerge. Gene regulatory evolution is widespread and accumulates with genetic divergence in both insects and nematodes. Divergence in cis is more common than divergence in trans. Coevolution between cis and trans shows a particular increase over greater evolutionary timespans, especially in sex-specific gene regulation. Despite these generalities, the evolution of gene regulation is gene- and taxon-specific. The congruence of these conclusions with evidence from other types of experiments suggests that general principles are discoverable, and a unified view of the tempo and mode of regulatory evolution may be achievable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.