ArticlePLoS pathogens2012
Historical contingencies modulate the adaptability of Rice yellow mottle virus.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 53 citations in OpenAlex.
- Grains, trade and war in the multimodal transmission of Rice yellow mottle virus: An historical and phylogeographical retrospective.PLoS pathogens · 2025Article
- Rice Yellow Mottle Virus (RYMV): A Review.Viruses · 2024Review
- Revisiting the origins of the Sobemovirus genus: A case for ancient origins of plant viruses.PLoS pathogens · 2024Article
- Genetic diversity and epidemic histories of rice yellow mottle virus in Ghana.Virus research · 2023Article
- Molecular Tools to Infer Resistance-Breaking Abilities of Rice Yellow Mottle Virus Isolates.Viruses · 2023Article
- Reversion of a resistance-breaking mutation shows reversion costs and high virus diversity at necrotic local lesions.Molecular plant pathology · 2023Article
- Article
- Insights Into Natural Genetic Resistance to Rice Yellow Mottle Virus and Implications on Breeding for Durable Resistance.Frontiers in plant science · 2021Review
- Article
- Analysis of Fitness Trade-Offs in the Host Range Expansion of an RNA Virus, Tobacco Mild Green Mosaic Virus.Journal of virology · 2018Article
- Pathogenicity of rice yellow mottle virus and screening of rice accessions from the Central African Republic.Virology journal · 2018Article
- Pleiotropic Effects of Resistance-Breaking Mutations on Particle Stability Provide Insight into Life History Evolution of a Plant RNA Virus.Journal of virology · 2017Article
- Fine mapping of RYMV3: a new resistance gene to Rice yellow mottle virus from Oryza glaberrima.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Mutations That Determine Resistance Breaking in a Plant RNA Virus Have Pleiotropic Effects on Its Fitness That Depend on the Host Environment and on the Type, Single or Mixed, of Infection.Journal of virology · 2016Article
- Adaptation to resistant hosts increases fitness on susceptible hosts in the plant parasitic nematode Globodera pallida.Ecology and evolution · 2016Article
- Mutations inFrontiers in plant science · 2016Article
- Plant Translation Factors and Virus Resistance.Viruses · 2015Review
- Overview on Sobemoviruses and a Proposal for the Creation of the Family Sobemoviridae.Viruses · 2015Review
- Interaction patterns between potato virus Y and eIF4E-mediated recessive resistance in the Solanaceae.Journal of virology · 2014Article
- Genotypic but not phenotypic historical contingency revealed by viral experimental evolution.BMC evolutionary biology · 2013Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rymv1-2 and rymv1-3 alleles of the RYMV1 resistance to Rice yellow mottle virus (RYMV), coded by an eIF(iso)4G1 gene, occur in a few cultivars of the Asiatic (Oryza sativa) and African (O. glaberrima) rice species, respectively. The most salient feature of the resistance breaking (RB) process is the converse genetic barrier to rymv1-2 and rymv1-3 resistance breakdown. This specificity is modulated by the amino acid (glutamic acid vs. threonine) at codon 49 of the Viral Protein genome-linked (VPg), a position which is adjacent to the virulence codons 48 and 52. Isolates with a glutamic acid (E) do not overcome rymv1-3 whereas those with a threonine (T) rarely overcome rymv1-2. We found that isolates with T49 had a strong selective advantage over isolates with E49 in O. glaberrima susceptible cultivars. This explains the fixation of the mutation T49 during RYMV evolution and accounts for the diversifying selection estimated at codon 49. Better adapted to O. glaberrima, isolates with T49 are also more prone than isolates with E49 to fix rymv1-3 RB mutations at codon 52 in resistant O. glaberrima cultivars. However, subsequent genetic constraints impaired the ability of isolates with T49 to fix rymv1-2 RB mutations at codons 48 and 52 in resistant O. sativa cultivars. The origin and role of the amino acid at codon 49 of the VPg exemplifies the importance of historical contingencies in the ability of RYMV to overcome RYMV1 resistance.
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